Version history

{
  "scope": "Mouse A1, awake; two-photon imaging + whole-cell + computational model",
  "claim_text": "Recurrent network dynamics in mouse primary auditory cortex (A1) shape direction selectivity by differentially amplifying inputs in the recurrent circuitry between preferred and non-preferred directions — not by classical feedforward temporal offsets.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/s41467-020-20590-6",
    "claim": "Recurrent network dynamics in mouse primary auditory cortex (A1) shape direction selectivity by differentially amplifying inputs in the recurrent circuitry between preferred and non-preferred directions — not by classical feedforward temporal offsets.",
    "cite_key": "Aponte2021",
    "evidence": "Two-photon imaging and whole-cell recording in awake mouse A1 with frequency-modulated tone sweeps; biophysical model of recurrent A1 circuitry.",
    "effect_size": "asymmetry in excitatory postsynaptic charge between FM directions is enhanced within A1 (nonlinear amplification of thalamic input)",
    "text_access": "fulltext",
    "study_system": "Mouse A1, awake; two-photon imaging + whole-cell + computational model",
    "argument_role": "supporting",
    "replication_status": "within_lab",
    "claim_source_sentence": "In contrast to classical models, we found that direction selectivity is not caused by temporal offsets between feedforward synaptic inputs; rather, it is generated due to differential amplification of input signals in the recurrent circuitry between preferred and non-preferred directions.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2017.06.019"
    ],
    "effect_size_source_sentence": "Our data indicate that the asymmetry in excitatory postsynaptic charge between FM directions is enhanced within A1, suggesting a nonlinear amplification of thalamic inputs in cortical circuitry."
  },
  "section_id": "section_09",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "effect_size": "asymmetry in excitatory postsynaptic charge between FM directions is enhanced within A1 (nonlinear amplification of thalamic input)",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "source_kind": "review_finding",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-b6f844c72f1a"
  ],
  "source_span": "In contrast to classical models, we found that direction selectivity is not caused by temporal offsets between feedforward synaptic inputs; rather, it is generated due to differential amplification of input signals in the recurrent circuitry between preferred and non-preferred directions.",
  "study_system": "Mouse A1, awake; two-photon imaging + whole-cell + computational model",
  "evidence_refs": [
    {
      "ref": "paper:paper-b6f844c72f1a"
    }
  ],
  "section_title": "9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation",
  "source_policy": {
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    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Two-photon imaging and whole-cell recording in awake mouse A1 with frequency-modulated tone sweeps; biophysical model of recurrent A1 circuitry.",
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  "replication_status": "within_lab",
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  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}