- claim_text
Recurrent network dynamics in mouse primary auditory cortex (A1) shape direction selectivity by differentially amplifying inputs in the recurrent circuitry between preferred and non-preferred directions — not by classical feedforward temporal offsets.
- raw_fields
{
"n": 0,
"doi": "10.1038/s41467-020-20590-6",
"claim": "Recurrent network dynamics in mouse primary auditory cortex (A1) shape direction selectivity by differentially amplifying inputs in the recurrent circuitry between preferred and non-preferred directions — not by classical feedforward temporal offsets.",
"cite_key": "Aponte2021",
"evidence": "Two-photon imaging and whole-cell recording in awake mouse A1 with frequency-modulated tone sweeps; biophysical model of recurrent A1 circuitry.",
"effect_size": "asymmetry in excitatory postsynaptic charge between FM directions is enhanced within A1 (nonlinear amplification of thalamic input)",
"text_access": "fulltext",
"study_system": "Mouse A1, awake; two-photon imaging + whole-cell + computational model",
"argument_role": "supporting",
"replication_status": "within_lab",
"claim_source_sentence": "In contrast to classical models, we found that direction selectivity is not caused by temporal offsets between feedforward synaptic inputs; rather, it is generated due to differential amplification of input signals in the recurrent circuitry between preferred and non-preferred directions.",
"source_provenance_status": "ok",
"replication_evidence_dois": [
"10.1016/j.neuron.2017.06.019"
],
"effect_size_source_sentence": "Our data indicate that the asymmetry in excitatory postsynaptic charge between FM directions is enhanced within A1, suggesting a nonlinear amplification of thalamic inputs in cortical circuitry."
}- source_refs
[
"paper:paper-b6f844c72f1a"
]
- source_span
In contrast to classical models, we found that direction selectivity is not caused by temporal offsets between feedforward synaptic inputs; rather, it is generated due to differential amplification of input signals in the recurrent circuitry between preferred and non-preferred directions.
- evidence_refs
[
{
"ref": "paper:paper-b6f844c72f1a"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}