Version history

{
  "scope": "mouse, freely behaving",
  "claim_text": "Targeted optogenetic activation of D1 vs D2-receptor-expressing striatal projection neurons elicits opposing motor effects, supporting the canonical direct/indirect pathway model in freely behaving mice.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.bbr.2013.04.018",
    "claim": "Targeted optogenetic activation of D1 vs D2-receptor-expressing striatal projection neurons elicits opposing motor effects, supporting the canonical direct/indirect pathway model in freely behaving mice.",
    "cite_key": "Lenz2013",
    "evidence": "Review summarizing ChR2 manipulations in D1-Cre and A2A-Cre mice (e.g., Kravitz 2010 and follow-ups).",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "mouse, freely behaving",
    "source_cluster_id": "cluster_10",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Recent breakthroughs in optogenetic technologies to alter neuronal firing and function with light, combined with cell type-specific transgenic animal lines, has led to important insights into the function of distinct neuronal cell subtypes and afferent connections in the heterogeneously complex striatum.",
    "replication_evidence_dois": [
      "10.1016/j.expneurol.2016.09.009",
      "10.1523/jneurosci.1278-13.2013"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewLoops",
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  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-74401b6c3fd2"
  ],
  "source_span": "Recent breakthroughs in optogenetic technologies to alter neuronal firing and function with light, combined with cell type-specific transgenic animal lines, has led to important insights into the function of distinct neuronal cell subtypes and afferent connections in the heterogeneously complex striatum.",
  "study_system": "mouse, freely behaving",
  "evidence_refs": [
    {
      "ref": "paper:paper-74401b6c3fd2"
    }
  ],
  "section_title": "Cell-Type-Specific Dissection of Loop Circuits (Opto/Chemo/Tracing)",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Review summarizing ChR2 manipulations in D1-Cre and A2A-Cre mice (e.g., Kravitz 2010 and follow-ups).",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-11",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
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}