Version history

{
  "scope": "mouse, embryonic GE (E13.5 MGE / E14.5 CGE+LGE)",
  "claim_text": "All three ganglionic eminences (MGE, CGE, LGE) share a highly conserved transcriptomic maturation trajectory through mitotic progenitors, while eminence-specific transcription factor expression — overlaid on this conserved trajectory — seeds the emergence of cardinal interneuron diversity at the postmitotic stage.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/nature25999",
    "claim": "All three ganglionic eminences (MGE, CGE, LGE) share a highly conserved transcriptomic maturation trajectory through mitotic progenitors, while eminence-specific transcription factor expression — overlaid on this conserved trajectory — seeds the emergence of cardinal interneuron diversity at the postmitotic stage.",
    "title": null,
    "cite_key": "Mayer2018",
    "evidence": "Drop-seq scRNA-seq of dissected E13.5 MGE and E14.5 CGE+LGE from mouse embryos; principal-curve maturation trajectory; PCA + reverse graph embedding cross-validation.",
    "effect_size": "Single shared maturation trajectory across all three GE; eminence-specific TFs only after diverging into precursor states",
    "figure_data": [],
    "text_access": "fulltext",
    "study_system": "mouse, embryonic GE (E13.5 MGE / E14.5 CGE+LGE)",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "primary",
    "_source_cluster_index": 91,
    "claim_source_sentence": "Heterogeneity within mitotic progenitors in the ganglionic eminences is driven by a highly conserved maturation trajectory, alongside eminence-specific transcription factor expression that seeds the emergence of later diversity. Upon becoming postmitotic, progenitors diverge and differentiate into transcriptionally distinct states, including an interneuron precursor state.",
    "replication_evidence_dois": [
      "10.1038/nature25980"
    ],
    "effect_size_source_sentence": "Within mitotic progenitors, we found a highly conserved maturation trajectory, accompanied by eminence-specific transcription factor expression that seeds the emergence of later cell diversity."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": "Single shared maturation trajectory across all three GE; eminence-specific TFs only after diverging into precursor states",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-c3e9fd7af6d3"
  ],
  "source_span": "Heterogeneity within mitotic progenitors in the ganglionic eminences is driven by a highly conserved maturation trajectory, alongside eminence-specific transcription factor expression that seeds the emergence of later diversity. Upon becoming postmitotic, progenitors diverge and differentiate into transcriptionally distinct states, including an interneuron precursor state.",
  "study_system": "mouse, embryonic GE (E13.5 MGE / E14.5 CGE+LGE)",
  "evidence_refs": [
    {
      "ref": "paper:paper-c3e9fd7af6d3"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Drop-seq scRNA-seq of dissected E13.5 MGE and E14.5 CGE+LGE from mouse embryos; principal-curve maturation trajectory; PCA + reverse graph embedding cross-validation.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "primary",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}