All three ganglionic eminences (MGE, CGE, LGE) share a highly conserved transcr…

All three ganglionic eminences (MGE, CGE, LGE) share a highly conserved transcriptomic maturation trajectory through mitotic progenitors, while eminence-specific transcription factor expression — overlaid on this conserved trajectory — seeds the emergence of cardinal interneuron diversity at the postmitotic stage.

{
  "n": null,
  "doi": "10.1038/nature25999",
  "claim": "All three ganglionic eminences (MGE, CGE, LGE) share a highly conserved transcriptomic maturation trajectory through mitotic progenitors, while eminence-specific transcription factor expression — overlaid on this conserved trajectory — seeds the emergence of cardinal interneuron diversity at the postmitotic stage.",
  "title": null,
  "cite_key": "Mayer2018",
  "evidence": "Drop-seq scRNA-seq of dissected E13.5 MGE and E14.5 CGE+LGE from mouse embryos; principal-curve maturation trajectory; PCA + reverse graph embedding cross-validation.",
  "effect_size": "Single shared maturation trajectory across all three GE; eminence-specific TFs only after diverging into precursor states",
  "figure_data": [],
  "text_access": "fulltext",
  "study_system": "mouse, embryonic GE (E13.5 MGE / E14.5 CGE+LGE)",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "primary",
  "_source_cluster_index": 91,
  "claim_source_sentence": "Heterogeneity within mitotic progenitors in the ganglionic eminences is driven by a highly conserved maturation trajectory, alongside eminence-specific transcription factor expression that seeds the emergence of later diversity. Upon becoming postmitotic, progenitors diverge and differentiate into transcriptionally distinct states, including an interneuron precursor state.",
  "replication_evidence_dois": [
    "10.1038/nature25980"
  ],
  "effect_size_source_sentence": "Within mitotic progenitors, we found a highly conserved maturation trajectory, accompanied by eminence-specific transcription factor expression that seeds the emergence of later cell diversity."
}

[
  "paper:paper-c3e9fd7af6d3"
]

Heterogeneity within mitotic progenitors in the ganglionic eminences is driven by a highly conserved maturation trajectory, alongside eminence-specific transcription factor expression that seeds the emergence of later diversity. Upon becoming postmitotic, progenitors diverge and differentiate into transcriptionally distinct states, including an interneuron precursor state.

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