Version history

{
  "scope": "mouse, opto-fMRI, D1- vs D2-receptor SPN stimulation",
  "claim_text": "Whole-brain fMRI during cell-type-specific D1/D2 SPN stimulation revealed broadly opposing downstream responses in thalamus, GPi, and STN, supporting an opposing-pathway influence on brain-wide circuitry while showing the actual pattern is more nuanced than simple two-pathway models predict.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.neuron.2016.06.010",
    "claim": "Whole-brain fMRI during cell-type-specific D1/D2 SPN stimulation revealed broadly opposing downstream responses in thalamus, GPi, and STN, supporting an opposing-pathway influence on brain-wide circuitry while showing the actual pattern is more nuanced than simple two-pathway models predict.",
    "cite_key": "Lee2016",
    "evidence": "",
    "effect_size": "opposing BOLD responses in thalamus, GPi, STN with D1 vs D2 stimulation",
    "text_access": "fulltext",
    "study_system": "mouse, opto-fMRI, D1- vs D2-receptor SPN stimulation",
    "source_cluster_id": "cluster_04",
    "replication_status": "replicated",
    "claim_source_sentence": "Unlike the BOLD signals observed at the site of stimulation in striatum, the fMRI BOLD signals in thalamus exhibited opposite responses during D1- and D2-MSN stimulation.",
    "replication_evidence_dois": [
      "10.1038/nature09159"
    ],
    "effect_size_source_sentence": "Excitation of either inhibitory population evoked robust positive BOLD signals within striatum, while downstream regions exhibited significantly different and generally opposing responses consistent with-though not easily predicted from-contemporary models of basal ganglia function."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_05_evidence_package.json",
  "effect_size": "opposing BOLD responses in thalamus, GPi, STN with D1 vs D2 stimulation",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-05",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-b849240e219b"
  ],
  "source_span": "Unlike the BOLD signals observed at the site of stimulation in striatum, the fMRI BOLD signals in thalamus exhibited opposite responses during D1- and D2-MSN stimulation.",
  "study_system": "mouse, opto-fMRI, D1- vs D2-receptor SPN stimulation",
  "evidence_refs": [
    {
      "ref": "paper:paper-b849240e219b"
    }
  ],
  "section_title": "Pallidal Organization and the Disinhibition Principle",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-05",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_05_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}