Whole-brain fMRI during cell-type-specific D1/D2 SPN stimulation revealed broad…

Whole-brain fMRI during cell-type-specific D1/D2 SPN stimulation revealed broadly opposing downstream responses in thalamus, GPi, and STN, supporting an opposing-pathway influence on brain-wide circuitry while showing the actual pattern is more nuanced than simple two-pathway models predict.

{
  "n": 0,
  "doi": "10.1016/j.neuron.2016.06.010",
  "claim": "Whole-brain fMRI during cell-type-specific D1/D2 SPN stimulation revealed broadly opposing downstream responses in thalamus, GPi, and STN, supporting an opposing-pathway influence on brain-wide circuitry while showing the actual pattern is more nuanced than simple two-pathway models predict.",
  "cite_key": "Lee2016",
  "evidence": "",
  "effect_size": "opposing BOLD responses in thalamus, GPi, STN with D1 vs D2 stimulation",
  "text_access": "fulltext",
  "study_system": "mouse, opto-fMRI, D1- vs D2-receptor SPN stimulation",
  "source_cluster_id": "cluster_04",
  "replication_status": "replicated",
  "claim_source_sentence": "Unlike the BOLD signals observed at the site of stimulation in striatum, the fMRI BOLD signals in thalamus exhibited opposite responses during D1- and D2-MSN stimulation.",
  "replication_evidence_dois": [
    "10.1038/nature09159"
  ],
  "effect_size_source_sentence": "Excitation of either inhibitory population evoked robust positive BOLD signals within striatum, while downstream regions exhibited significantly different and generally opposing responses consistent with-though not easily predicted from-contemporary models of basal ganglia function."
}

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