Details
- scope
- mouse, V1, ChR2 optogenetics
- claim_text
- Optogenetic activation of PV+ interneurons in mouse V1 sharpens orientation tuning and improves perceptual discrimination
- section_id
- section_08_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_08_evidence_package.json
- effect_size
- significant sharpening of orientation tuning; improved orientation discrimination in awake mice
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-08
- source_kind
- review_finding
- source_path
- evidence/section_08_evidence_package.json
- source_span
- elevated spiking of PV+ interneurons markedly sharpened orientation tuning and enhanced direction selectivity of nearby neurons
- study_system
- mouse, V1, ChR2 optogenetics
- section_title
- In Vivo Dynamics and Behavioural Correlates
- evidence_summary
- PV+ activation sharpened orientation tuning and improved behavioral discrimination; SOM+ and VIP+ activation had no significant effect on selectivity
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-08
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_08_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1038/nature11312", "claim": "Optogenetic activation of PV+ interneurons in mouse V1 sharpens orientation tuning and improves perceptual discrimination", "evidence": "PV+ activation sharpened orientation tuning and improved behavioral discrimination; SOM+ and VIP+ activation had no significant effect on selectivity", "effect_size": "significant sharpening of orientation tuning; improved orientation discrimination in awake mice", "text_access": "fulltext", "study_system": "mouse, V1, ChR2 optogenetics", "replication_status": "independently_replicated", "claim_source_sentence": "elevated spiking of PV+ interneurons markedly sharpened orientation tuning and enhanced direction selectivity of nearby neurons", "replication_evidence_dois": [ "10.1016/j.neuron.2011.12.013" ], "effect_size_source_sentence": "PV+ neuron activation in awake mice caused a significant improvement in their orientation discrimination, mirroring the sharpened V1 orientation tuning" }- source_refs
[ "paper:paper-89a90cbbebc9" ]
- evidence_refs
[ { "ref": "paper:paper-89a90cbbebc9" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }