Version history

{
  "scope": "mouse, V1, ChR2 optogenetics",
  "claim_text": "Optogenetic activation of PV+ interneurons in mouse V1 sharpens orientation tuning and improves perceptual discrimination",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/nature11312",
    "claim": "Optogenetic activation of PV+ interneurons in mouse V1 sharpens orientation tuning and improves perceptual discrimination",
    "evidence": "PV+ activation sharpened orientation tuning and improved behavioral discrimination; SOM+ and VIP+ activation had no significant effect on selectivity",
    "effect_size": "significant sharpening of orientation tuning; improved orientation discrimination in awake mice",
    "text_access": "fulltext",
    "study_system": "mouse, V1, ChR2 optogenetics",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "elevated spiking of PV+ interneurons markedly sharpened orientation tuning and enhanced direction selectivity of nearby neurons",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2011.12.013"
    ],
    "effect_size_source_sentence": "PV+ neuron activation in awake mice caused a significant improvement in their orientation discrimination, mirroring the sharpened V1 orientation tuning"
  },
  "section_id": "section_08_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_08_evidence_package.json",
  "effect_size": "significant sharpening of orientation tuning; improved orientation discrimination in awake mice",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-08",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-89a90cbbebc9"
  ],
  "source_span": "elevated spiking of PV+ interneurons markedly sharpened orientation tuning and enhanced direction selectivity of nearby neurons",
  "study_system": "mouse, V1, ChR2 optogenetics",
  "evidence_refs": [
    {
      "ref": "paper:paper-89a90cbbebc9"
    }
  ],
  "section_title": "In Vivo Dynamics and Behavioural Correlates",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "PV+ activation sharpened orientation tuning and improved behavioral discrimination; SOM+ and VIP+ activation had no significant effect on selectivity",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-08",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_08_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}