Version history

{
  "scope": "Awake mice; LP and LP→A1 optogenetic manipulation + A1 recording.",
  "claim_text": "In awake mice, bidirectional activity modulations of lateral posterior thalamus (LP, pulvinar homologue) sharpen receptive fields, frequency tuning and signal-to-noise of primary auditory cortex (A1) supragranular neurons through a subtractive-suppression mechanism via LP-to-A1 axons targeting specific L1/superficial inhibitory neurons — implicating trans-thalamic cortico-cortical pathways in cross-modal cortical processing.",
  "raw_fields": {
    "n": null,
    "doi": "10.7554/elife.54157",
    "claim": "In awake mice, bidirectional activity modulations of lateral posterior thalamus (LP, pulvinar homologue) sharpen receptive fields, frequency tuning and signal-to-noise of primary auditory cortex (A1) supragranular neurons through a subtractive-suppression mechanism via LP-to-A1 axons targeting specific L1/superficial inhibitory neurons — implicating trans-thalamic cortico-cortical pathways in cross-modal cortical processing.",
    "cite_key": "Chou2020",
    "evidence": "Optogenetic bidirectional manipulation of LP and LP→A1 axons in awake mice + electrophysiological/two-photon recording in A1.",
    "effect_size": "LP→A1 axon activity sharpens A1 RFs, frequency tuning and SNR via subtractive suppression mediated by L1/superficial inhibitory neurons.",
    "text_access": "abstract_only",
    "study_system": "Awake mice; LP and LP→A1 optogenetic manipulation + A1 recording.",
    "argument_role": "supporting",
    "replication_status": "not_yet",
    "claim_source_sentence": "LP improves auditory processing in A1 supragranular-layer neurons by sharpening their receptive fields and frequency tuning, as well as increasing the signal-to-noise ratio (SNR).",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "This is achieved through a subtractive-suppression mechanism, mediated largely by LP-to-A1 axons preferentially innervating specific inhibitory neurons in layer 1 and superficial layer."
  },
  "section_id": "section_08",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "effect_size": "LP→A1 axon activity sharpens A1 RFs, frequency tuning and SNR via subtractive suppression mediated by L1/superficial inhibitory neurons.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-a8cf52ebf75a"
  ],
  "source_span": "LP improves auditory processing in A1 supragranular-layer neurons by sharpening their receptive fields and frequency tuning, as well as increasing the signal-to-noise ratio (SNR).",
  "study_system": "Awake mice; LP and LP→A1 optogenetic manipulation + A1 recording.",
  "evidence_refs": [
    {
      "ref": "paper:paper-a8cf52ebf75a"
    }
  ],
  "section_title": "8. Cross-areal mouse cortico-cortical excitatory connectivity — hierarchical feedforward and feedback as recurrent loops at the network level; Allen Mouse Connectivity Atlas anchored views",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Optogenetic bidirectional manipulation of LP and LP→A1 axons in awake mice + electrophysiological/two-photon recording in A1.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "not_yet",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}