In awake mice, bidirectional activity modulations of lateral posterior thalamus…

In awake mice, bidirectional activity modulations of lateral posterior thalamus (LP, pulvinar homologue) sharpen receptive fields, frequency tuning and signal-to-noise of primary auditory cortex (A1) supragranular neurons through a subtractive-suppression mechanism via LP-to-A1 axons targeting specific L1/superficial inhibitory neurons — implicating trans-thalamic cortico-cortical pathways in cross-modal cortical processing.

{
  "n": null,
  "doi": "10.7554/elife.54157",
  "claim": "In awake mice, bidirectional activity modulations of lateral posterior thalamus (LP, pulvinar homologue) sharpen receptive fields, frequency tuning and signal-to-noise of primary auditory cortex (A1) supragranular neurons through a subtractive-suppression mechanism via LP-to-A1 axons targeting specific L1/superficial inhibitory neurons — implicating trans-thalamic cortico-cortical pathways in cross-modal cortical processing.",
  "cite_key": "Chou2020",
  "evidence": "Optogenetic bidirectional manipulation of LP and LP→A1 axons in awake mice + electrophysiological/two-photon recording in A1.",
  "effect_size": "LP→A1 axon activity sharpens A1 RFs, frequency tuning and SNR via subtractive suppression mediated by L1/superficial inhibitory neurons.",
  "text_access": "abstract_only",
  "study_system": "Awake mice; LP and LP→A1 optogenetic manipulation + A1 recording.",
  "argument_role": "supporting",
  "replication_status": "not_yet",
  "claim_source_sentence": "LP improves auditory processing in A1 supragranular-layer neurons by sharpening their receptive fields and frequency tuning, as well as increasing the signal-to-noise ratio (SNR).",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "This is achieved through a subtractive-suppression mechanism, mediated largely by LP-to-A1 axons preferentially innervating specific inhibitory neurons in layer 1 and superficial layer."
}

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