Version history

{
  "scope": "male mouse, lateral globus pallidus",
  "claim_text": "A chimeric light-activated DRD2 (OptoDRD2) expressed in glutamatergic neurons of the lateral globus pallidus drives DRD2-like Gαi/o signaling and increases locomotion in male mice.",
  "raw_fields": {
    "n": 8,
    "doi": "10.1523/jneurosci.1473-24.2024",
    "claim": "A chimeric light-activated DRD2 (OptoDRD2) expressed in glutamatergic neurons of the lateral globus pallidus drives DRD2-like Gαi/o signaling and increases locomotion in male mice.",
    "cite_key": "Kim2024b",
    "evidence": "Cell-based cAMP/ERK assays + AAV expression in LGP excitatory neurons + open-field behavior.",
    "effect_size": "2",
    "text_access": "fulltext",
    "study_system": "male mouse, lateral globus pallidus",
    "source_cluster_id": "cluster_10",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "The optogenetic stimulation of OptoDRD2 in the LGP region affected a wide range of locomotion-related parameters, such as increased frequency of movement and decreased immobility time, resulting in the facilitation of motor function of living male mice.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "The optogenetic stimulation of OptoDRD2 in the LGP region affected a wide range of locomotion-related parameters, such as increased frequency of movement and decreased immobility time, resulting in the facilitation of motor function of living male mice."
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json",
  "effect_size": "2",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-11",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-620809df3687"
  ],
  "source_span": "The optogenetic stimulation of OptoDRD2 in the LGP region affected a wide range of locomotion-related parameters, such as increased frequency of movement and decreased immobility time, resulting in the facilitation of motor function of living male mice.",
  "study_system": "male mouse, lateral globus pallidus",
  "evidence_refs": [
    {
      "ref": "paper:paper-620809df3687"
    }
  ],
  "section_title": "Cell-Type-Specific Dissection of Loop Circuits (Opto/Chemo/Tracing)",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Cell-based cAMP/ERK assays + AAV expression in LGP excitatory neurons + open-field behavior.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-11",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}