- claim_text
Mouse forelimb S1 cortico-thalamo-cortical circuits are organized as cell-type-specific recurrent loops in which both L6 CT and L5B PT projection neurons provide the strongest excitatory input to those thalamocortical neurons that project back to S1.
- raw_fields
{
"n": 0,
"doi": "10.1523/jneurosci.2277-19.2020",
"claim": "Mouse forelimb S1 cortico-thalamo-cortical circuits are organized as cell-type-specific recurrent loops in which both L6 CT and L5B PT projection neurons provide the strongest excitatory input to those thalamocortical neurons that project back to S1.",
"cite_key": "Guo2020",
"evidence": "Cell-type-specific anterograde optogenetic excitation combined with single-cell recordings from retrogradely labeled thalamocortical neurons in mouse.",
"effect_size": "qualitative — recurrent CT and PT loops dominate over non-recurrent projections",
"text_access": "abstract_only",
"study_system": "mouse primary somatosensory cortex (forelimb S1) and motor thalamus, both sexes",
"argument_role": "supporting",
"replication_status": "independently_replicated",
"claim_source_sentence": "Collectively, our results reveal that C-T-C circuits of mouse forelimb S1 are primarily organized as multiple cortical cell-type-specific and thalamic subnucleus-specific recurrent loops, with both CT and PT neurons providing the strongest excitatory input to TC neurons that project back to S1.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [
"10.1523/JNEUROSCI.4023-14.2015",
"10.1523/JNEUROSCI.1333-18.2018"
],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-7c6266401771"
]
- source_span
Collectively, our results reveal that C-T-C circuits of mouse forelimb S1 are primarily organized as multiple cortical cell-type-specific and thalamic subnucleus-specific recurrent loops, with both CT and PT neurons providing the strongest excitatory input to TC neurons that project back to S1.
- evidence_refs
[
{
"ref": "paper:paper-7c6266401771"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}