Version history

{
  "scope": "mouse primary somatosensory cortex (forelimb S1) and motor thalamus, both sexes",
  "claim_text": "Mouse forelimb S1 cortico-thalamo-cortical circuits are organized as cell-type-specific recurrent loops in which both L6 CT and L5B PT projection neurons provide the strongest excitatory input to those thalamocortical neurons that project back to S1.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.2277-19.2020",
    "claim": "Mouse forelimb S1 cortico-thalamo-cortical circuits are organized as cell-type-specific recurrent loops in which both L6 CT and L5B PT projection neurons provide the strongest excitatory input to those thalamocortical neurons that project back to S1.",
    "cite_key": "Guo2020",
    "evidence": "Cell-type-specific anterograde optogenetic excitation combined with single-cell recordings from retrogradely labeled thalamocortical neurons in mouse.",
    "effect_size": "qualitative — recurrent CT and PT loops dominate over non-recurrent projections",
    "text_access": "abstract_only",
    "study_system": "mouse primary somatosensory cortex (forelimb S1) and motor thalamus, both sexes",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Collectively, our results reveal that C-T-C circuits of mouse forelimb S1 are primarily organized as multiple cortical cell-type-specific and thalamic subnucleus-specific recurrent loops, with both CT and PT neurons providing the strongest excitatory input to TC neurons that project back to S1.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1523/JNEUROSCI.4023-14.2015",
      "10.1523/JNEUROSCI.1333-18.2018"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "effect_size": "qualitative — recurrent CT and PT loops dominate over non-recurrent projections",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-7c6266401771"
  ],
  "source_span": "Collectively, our results reveal that C-T-C circuits of mouse forelimb S1 are primarily organized as multiple cortical cell-type-specific and thalamic subnucleus-specific recurrent loops, with both CT and PT neurons providing the strongest excitatory input to TC neurons that project back to S1.",
  "study_system": "mouse primary somatosensory cortex (forelimb S1) and motor thalamus, both sexes",
  "evidence_refs": [
    {
      "ref": "paper:paper-7c6266401771"
    }
  ],
  "section_title": "7. Cell-type-specific E→E motifs in mouse — IT vs PT vs CT pyramidal projection classes; L5 thick-tufted recurrence; Patch-seq and Allen mouse-cortex taxonomy intersections; transcriptomic-type-specific connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Cell-type-specific anterograde optogenetic excitation combined with single-cell recordings from retrogradely labeled thalamocortical neurons in mouse.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}