Details
- scope
- MPTP-treated nonhuman primates
- claim_text
- MPTP-treated primates with parkinsonism show increased basal-ganglia output rates (GPi/SNr hyperactivity) consistent with the indirect-pathway hyperkinesia model
- section_id
- section_05
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_05_evidence_package.json
- effect_size
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-05
- source_kind
- review_finding
- source_path
- evidence/section_05_evidence_package.json
- source_span
- Both extremes of this movement disorder spectrum can be accounted for by postulating specific disturbances within the basal ganglia-thalamocortical 'motor' circuit.
- study_system
- MPTP-treated nonhuman primates
- section_title
- Pallidal Organization and the Disinhibition Principle
- evidence_summary
- Single-unit recording in MPTP primates linking circuit dysfunction to clinical motor signs
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-05
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_05_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1016/0166-2236(90)90110-v", "claim": "MPTP-treated primates with parkinsonism show increased basal-ganglia output rates (GPi/SNr hyperactivity) consistent with the indirect-pathway hyperkinesia model", "cite_key": "DeLong1990", "evidence": "Single-unit recording in MPTP primates linking circuit dysfunction to clinical motor signs", "effect_size": "", "text_access": "abstract_only", "study_system": "MPTP-treated nonhuman primates", "source_cluster_id": "cluster_04", "replication_status": "independently_replicated", "claim_source_sentence": "Both extremes of this movement disorder spectrum can be accounted for by postulating specific disturbances within the basal ganglia-thalamocortical 'motor' circuit.", "replication_evidence_dois": [ "10.1523/jneurosci.23-05-01916.2003", "10.1016/0166-2236(89)90074-x" ], "effect_size_source_sentence": null }- source_refs
[ "paper:paper-d7b8b0eb6812" ]
- evidence_refs
[ { "ref": "paper:paper-d7b8b0eb6812" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }