Version history

{
  "scope": "rat hippocampal basket cells and CA1 pyramidal neurons",
  "claim_text": "Fast-spiking interneurons are distinguished from pyramidal neurons by predominant expression of a fast delayed rectifier K+ current component (Kv3-mediated), contributing 58% of total K+ current, whereas pyramidal neurons express primarily A-type K+ currents (Kv4-mediated).",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.18-20-08111.1998",
    "claim": "Fast-spiking interneurons are distinguished from pyramidal neurons by predominant expression of a fast delayed rectifier K+ current component (Kv3-mediated), contributing 58% of total K+ current, whereas pyramidal neurons express primarily A-type K+ currents (Kv4-mediated).",
    "evidence": "Nucleated patch recordings from hippocampal basket cells vs CA1 pyramidal neurons with single-cell RT-PCR. Kv3 (Kv3.1, Kv3.2) transcripts in 89% of interneurons vs 17% of pyramidal neurons.",
    "effect_size": "58% of total K+ current from fast delayed rectifier in FS cells; Kv3 transcripts in 89% of interneurons vs 17% of pyramidal neurons",
    "text_access": "abstract_only",
    "study_system": "rat hippocampal basket cells and CA1 pyramidal neurons",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "In nucleated patches isolated from basket cells of the dentate gyrus, a fast delayed rectifier K+ current component that was highly sensitive to tetraethylammonium (TEA) and 4-aminopyridine (4-AP) predominated, contributing an average of 58% to the total K+ current in these cells.",
    "replication_evidence_dois": [
      "10.1523/jneurosci.19-21-09332.1999"
    ],
    "effect_size_source_sentence": "Kv3 (Kv3.1, Kv3.2) subunit transcripts were expressed in almost all (89%) of the interneurons but only in 17% of the pyramidal neurons."
  },
  "section_id": "section_05_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "effect_size": "58% of total K+ current from fast delayed rectifier in FS cells; Kv3 transcripts in 89% of interneurons vs 17% of pyramidal neurons",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-05",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-189d93ef8a30"
  ],
  "source_span": "In nucleated patches isolated from basket cells of the dentate gyrus, a fast delayed rectifier K+ current component that was highly sensitive to tetraethylammonium (TEA) and 4-aminopyridine (4-AP) predominated, contributing an average of 58% to the total K+ current in these cells.",
  "study_system": "rat hippocampal basket cells and CA1 pyramidal neurons",
  "evidence_refs": [
    {
      "ref": "paper:paper-189d93ef8a30"
    }
  ],
  "section_title": "Intrinsic Electrophysiology: The Fast-Spiking Phenotype and Its Variants",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Nucleated patch recordings from hippocampal basket cells vs CA1 pyramidal neurons with single-cell RT-PCR. Kv3 (Kv3.1, Kv3.2) transcripts in 89% of interneurons vs 17% of pyramidal neurons.",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-05",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}