- claim_text
Fast-spiking interneurons are distinguished from pyramidal neurons by predominant expression of a fast delayed rectifier K+ current component (Kv3-mediated), contributing 58% of total K+ current, whereas pyramidal neurons express primarily A-type K+ currents (Kv4-mediated).
- raw_fields
{
"n": 0,
"doi": "10.1523/jneurosci.18-20-08111.1998",
"claim": "Fast-spiking interneurons are distinguished from pyramidal neurons by predominant expression of a fast delayed rectifier K+ current component (Kv3-mediated), contributing 58% of total K+ current, whereas pyramidal neurons express primarily A-type K+ currents (Kv4-mediated).",
"evidence": "Nucleated patch recordings from hippocampal basket cells vs CA1 pyramidal neurons with single-cell RT-PCR. Kv3 (Kv3.1, Kv3.2) transcripts in 89% of interneurons vs 17% of pyramidal neurons.",
"effect_size": "58% of total K+ current from fast delayed rectifier in FS cells; Kv3 transcripts in 89% of interneurons vs 17% of pyramidal neurons",
"text_access": "abstract_only",
"study_system": "rat hippocampal basket cells and CA1 pyramidal neurons",
"replication_status": "independently_replicated",
"claim_source_sentence": "In nucleated patches isolated from basket cells of the dentate gyrus, a fast delayed rectifier K+ current component that was highly sensitive to tetraethylammonium (TEA) and 4-aminopyridine (4-AP) predominated, contributing an average of 58% to the total K+ current in these cells.",
"replication_evidence_dois": [
"10.1523/jneurosci.19-21-09332.1999"
],
"effect_size_source_sentence": "Kv3 (Kv3.1, Kv3.2) subunit transcripts were expressed in almost all (89%) of the interneurons but only in 17% of the pyramidal neurons."
}- source_refs
[
"paper:paper-189d93ef8a30"
]
- source_span
In nucleated patches isolated from basket cells of the dentate gyrus, a fast delayed rectifier K+ current component that was highly sensitive to tetraethylammonium (TEA) and 4-aminopyridine (4-AP) predominated, contributing an average of 58% to the total K+ current in these cells.
- evidence_refs
[
{
"ref": "paper:paper-189d93ef8a30"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}