Version history

{
  "scope": "mouse V1 L2/3, analytical/computational model constrained by optogenetic perturbation data",
  "claim_text": "The spatial radius of nearby excitation from single excitatory neuron perturbation in mouse V1 L2/3 (~70 μm for single-cell, ~35 μm for multi-cell) is significantly shorter than the E-to-E connectivity length scale (~125 μm), constraining models of excitatory-to-excitatory spatial connectivity.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1101/2024.12.27.630558",
    "claim": "The spatial radius of nearby excitation from single excitatory neuron perturbation in mouse V1 L2/3 (~70 μm for single-cell, ~35 μm for multi-cell) is significantly shorter than the E-to-E connectivity length scale (~125 μm), constraining models of excitatory-to-excitatory spatial connectivity.",
    "cite_key": "Chau2024",
    "evidence": "Exact analytical solution of a linear recurrent E-I network model with exponential-like spatial connectivity kernels fitted to mouse V1 L2/3 connection probability and synaptic strength data, compared to two-photon optogenetic single-cell perturbation measurements.",
    "effect_size": "E-to-E connectivity length scale ~125 μm vs. spatial radius of nearby excitation ~70 μm (single-cell) or ~35 μm (multi-cell perturbations)",
    "text_access": "fulltext",
    "study_system": "mouse V1 L2/3, analytical/computational model constrained by optogenetic perturbation data",
    "argument_role": "supporting",
    "replication_status": "consistent_with_prior",
    "claim_source_sentence": "Furthermore, the length scale ofconnectivity (standard deviation 125 μm for a Gaussian spatial profile, 12) is significantly broader than the spatial radius of nearby excitation (≈70 μm, 1), and an even shorter radius of excitation (≈35 μm) is seen for multi-cell perturbations, which could not be explained by a model with a Gaussian spatial profile for each connection ().",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Furthermore, the length scale ofconnectivity (standard deviation 125 μm for a Gaussian spatial profile, 12) is significantly broader than the spatial radius of nearby excitation (≈70 μm, 1), and an even shorter radius of excitation (≈35 μm) is seen for multi-cell perturbations, which could not be explained by a model with a Gaussian spatial profile for each connection ()."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "effect_size": "E-to-E connectivity length scale ~125 μm vs. spatial radius of nearby excitation ~70 μm (single-cell) or ~35 μm (multi-cell perturbations)",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-2d65a3bb4e0f"
  ],
  "source_span": "Furthermore, the length scale ofconnectivity (standard deviation 125 μm for a Gaussian spatial profile, 12) is significantly broader than the spatial radius of nearby excitation (≈70 μm, 1), and an even shorter radius of excitation (≈35 μm) is seen for multi-cell perturbations, which could not be explained by a model with a Gaussian spatial profile for each connection ().",
  "study_system": "mouse V1 L2/3, analytical/computational model constrained by optogenetic perturbation data",
  "evidence_refs": [
    {
      "ref": "paper:paper-2d65a3bb4e0f"
    }
  ],
  "section_title": "5. Horizontal long-range intracortical excitatory connections in mouse — patchy L2/3-L5 axons, similarity tuning, distance-decay",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Exact analytical solution of a linear recurrent E-I network model with exponential-like spatial connectivity kernels fitted to mouse V1 L2/3 connection probability and synaptic strength data, compared to two-photon optogenetic single-cell perturbation measurements.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "consistent_with_prior",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}