- claim_text
The spatial radius of nearby excitation from single excitatory neuron perturbation in mouse V1 L2/3 (~70 μm for single-cell, ~35 μm for multi-cell) is significantly shorter than the E-to-E connectivity length scale (~125 μm), constraining models of excitatory-to-excitatory spatial connectivity.
- raw_fields
{
"n": 0,
"doi": "10.1101/2024.12.27.630558",
"claim": "The spatial radius of nearby excitation from single excitatory neuron perturbation in mouse V1 L2/3 (~70 μm for single-cell, ~35 μm for multi-cell) is significantly shorter than the E-to-E connectivity length scale (~125 μm), constraining models of excitatory-to-excitatory spatial connectivity.",
"cite_key": "Chau2024",
"evidence": "Exact analytical solution of a linear recurrent E-I network model with exponential-like spatial connectivity kernels fitted to mouse V1 L2/3 connection probability and synaptic strength data, compared to two-photon optogenetic single-cell perturbation measurements.",
"effect_size": "E-to-E connectivity length scale ~125 μm vs. spatial radius of nearby excitation ~70 μm (single-cell) or ~35 μm (multi-cell perturbations)",
"text_access": "fulltext",
"study_system": "mouse V1 L2/3, analytical/computational model constrained by optogenetic perturbation data",
"argument_role": "supporting",
"replication_status": "consistent_with_prior",
"claim_source_sentence": "Furthermore, the length scale ofconnectivity (standard deviation 125 μm for a Gaussian spatial profile, 12) is significantly broader than the spatial radius of nearby excitation (≈70 μm, 1), and an even shorter radius of excitation (≈35 μm) is seen for multi-cell perturbations, which could not be explained by a model with a Gaussian spatial profile for each connection ().",
"source_provenance_status": "ok",
"replication_evidence_dois": [],
"effect_size_source_sentence": "Furthermore, the length scale ofconnectivity (standard deviation 125 μm for a Gaussian spatial profile, 12) is significantly broader than the spatial radius of nearby excitation (≈70 μm, 1), and an even shorter radius of excitation (≈35 μm) is seen for multi-cell perturbations, which could not be explained by a model with a Gaussian spatial profile for each connection ()."
}- source_refs
[
"paper:paper-2d65a3bb4e0f"
]
- source_span
Furthermore, the length scale ofconnectivity (standard deviation 125 μm for a Gaussian spatial profile, 12) is significantly broader than the spatial radius of nearby excitation (≈70 μm, 1), and an even shorter radius of excitation (≈35 μm) is seen for multi-cell perturbations, which could not be explained by a model with a Gaussian spatial profile for each connection ().
- evidence_refs
[
{
"ref": "paper:paper-2d65a3bb4e0f"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}- evidence_summary
Exact analytical solution of a linear recurrent E-I network model with exponential-like spatial connectivity kernels fitted to mouse V1 L2/3 connection probability and synaptic strength data, compared to two-photon optogenetic single-cell perturbation measurements.