Details
- scope
- Scn1a knock-in mice, developing neocortex
- claim_text
- Nav1.1 localizes predominantly to axon initial segments of PV interneurons in developing neocortex; Scn1a mutations cause spike amplitude decrement in fast-spiking cells
- section_id
- section_11_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json
- effect_size
- Pronounced spike amplitude decrement late in burst in heterozygous PV interneurons
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-11
- source_kind
- review_finding
- source_path
- evidence/section_11_evidence_package.json
- source_span
- Immunohistochemical analyses revealed that, in the developing neocortex, Nav1.1 was clustered predominantly at the axon initial segments of parvalbumin-positive (PV) interneurons.
- study_system
- Scn1a knock-in mice, developing neocortex
- section_title
- Species Translation, Human Data, and Disease Models
- evidence_summary
- Knock-in mouse study establishing cell-type basis for Dravet syndrome seizures
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-11
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1523/jneurosci.5270-06.2007", "claim": "Nav1.1 localizes predominantly to axon initial segments of PV interneurons in developing neocortex; Scn1a mutations cause spike amplitude decrement in fast-spiking cells", "evidence": "Knock-in mouse study establishing cell-type basis for Dravet syndrome seizures", "effect_size": "Pronounced spike amplitude decrement late in burst in heterozygous PV interneurons", "text_access": "abstract_only", "study_system": "Scn1a knock-in mice, developing neocortex", "replication_status": "independently_replicated", "claim_source_sentence": "Immunohistochemical analyses revealed that, in the developing neocortex, Nav1.1 was clustered predominantly at the axon initial segments of parvalbumin-positive (PV) interneurons.", "replication_evidence_dois": [ "10.1016/j.cell.2012.02.046" ], "effect_size_source_sentence": "In heterozygous knock-in mice, trains of evoked action potentials in these fast-spiking, inhibitory cells exhibited pronounced spike amplitude decrement late in the burst." }- source_refs
[ "paper:paper-fd8f15e7c2e1" ]
- evidence_refs
[ { "ref": "paper:paper-fd8f15e7c2e1" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }