Nav1.1 is clustered predominantly at the axon initial segments of parvalbumin-p…

Nav1.1 is clustered predominantly at the axon initial segments of parvalbumin-positive inhibitory interneurons in developing neocortex, and heterozygous Scn1a loss-of-function causes pronounced spike amplitude decrement during sustained firing in these fast-spiking cells.

{
  "n": 0,
  "doi": "10.1523/jneurosci.5270-06.2007",
  "claim": "Nav1.1 is clustered predominantly at the axon initial segments of parvalbumin-positive inhibitory interneurons in developing neocortex, and heterozygous Scn1a loss-of-function causes pronounced spike amplitude decrement during sustained firing in these fast-spiking cells.",
  "evidence": "Knock-in mouse line with loss-of-function nonsense mutation in Scn1a developed epileptic seizures within first postnatal month. Trains of evoked APs in PV-FS cells showed pronounced spike amplitude decrement late in burst.",
  "effect_size": "pronounced spike amplitude decrement in heterozygous knock-in FS cells during sustained burst firing",
  "text_access": "abstract_only",
  "study_system": "mouse neocortex, Scn1a knock-in model",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Immunohistochemical analyses revealed that, in the developing neocortex, Nav1.1 was clustered predominantly at the axon initial segments of parvalbumin-positive (PV) interneurons.",
  "replication_evidence_dois": [
    "10.1073/pnas.1411131111",
    "10.1523/jneurosci.0721-14.2014"
  ],
  "effect_size_source_sentence": "In heterozygous knock-in mice, trains of evoked action potentials in these fast-spiking, inhibitory cells exhibited pronounced spike amplitude decrement late in the burst."
}

[
  "paper:paper-fd8f15e7c2e1"
]

[
  {
    "ref": "paper:paper-fd8f15e7c2e1"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}