Version history

{
  "scope": "mouse prefrontal cortex layer 1, L5 PT and NDNF+/VIP+ interneurons",
  "claim_text": "In mouse prefrontal cortex (PFC), ventromedial (VM) and mediodorsal (MD) thalamic afferents target distinct sub-layers of layer 1 and engage non-overlapping interneuron classes: VM excites NDNF+ cells in L1a (which inhibit L5 PT apical dendrites and selectively suppress VM-evoked apical Ca²⁺ spikes), while MD excites VIP+ cells in L1b — producing parallel rather than convergent feed-forward L1 inhibitory circuits.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.neuron.2020.10.031",
    "claim": "In mouse prefrontal cortex (PFC), ventromedial (VM) and mediodorsal (MD) thalamic afferents target distinct sub-layers of layer 1 and engage non-overlapping interneuron classes: VM excites NDNF+ cells in L1a (which inhibit L5 PT apical dendrites and selectively suppress VM-evoked apical Ca²⁺ spikes), while MD excites VIP+ cells in L1b — producing parallel rather than convergent feed-forward L1 inhibitory circuits.",
    "cite_key": "Anastasiades2021",
    "evidence": "Anatomical tracing, ChR2-assisted optogenetics, whole-cell recordings and two-photon Ca²⁺ imaging of NDNF+ and VIP+ L1 interneurons and L5 PT pyramids in mouse PFC slices.",
    "effect_size": "qualitative — segregated VM-NDNF (L1a) vs MD-VIP (L1b) targeting in PFC L1",
    "text_access": "fulltext",
    "study_system": "mouse prefrontal cortex layer 1, L5 PT and NDNF+/VIP+ interneurons",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "VM engages NDNF+ cells in L1a, and MD drives VIP+ cells in L1b. These separate populations of L1 interneurons participate in different inhibitory networks in superficial layers by targeting either PV+ or SOM+ interneurons",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2018.03.024"
    ],
    "effect_size_source_sentence": "VM engages NDNF+ cells in L1a, and MD drives VIP+ cells in L1b"
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "effect_size": "qualitative — segregated VM-NDNF (L1a) vs MD-VIP (L1b) targeting in PFC L1",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-7227d2a3ed3e"
  ],
  "source_span": "VM engages NDNF+ cells in L1a, and MD drives VIP+ cells in L1b. These separate populations of L1 interneurons participate in different inhibitory networks in superficial layers by targeting either PV+ or SOM+ interneurons",
  "study_system": "mouse prefrontal cortex layer 1, L5 PT and NDNF+/VIP+ interneurons",
  "evidence_refs": [
    {
      "ref": "paper:paper-7227d2a3ed3e"
    }
  ],
  "section_title": "7. Cell-type-specific E→E motifs in mouse — IT vs PT vs CT pyramidal projection classes; L5 thick-tufted recurrence; Patch-seq and Allen mouse-cortex taxonomy intersections; transcriptomic-type-specific connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Anatomical tracing, ChR2-assisted optogenetics, whole-cell recordings and two-photon Ca²⁺ imaging of NDNF+ and VIP+ L1 interneurons and L5 PT pyramids in mouse PFC slices.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}