In mouse prefrontal cortex (PFC), ventromedial (VM) and mediodorsal (MD) thalam…

In mouse prefrontal cortex (PFC), ventromedial (VM) and mediodorsal (MD) thalamic afferents target distinct sub-layers of layer 1 and engage non-overlapping interneuron classes: VM excites NDNF+ cells in L1a (which inhibit L5 PT apical dendrites and selectively suppress VM-evoked apical Ca²⁺ spikes), while MD excites VIP+ cells in L1b — producing parallel rather than convergent feed-forward L1 inhibitory circuits.

{
  "n": 0,
  "doi": "10.1016/j.neuron.2020.10.031",
  "claim": "In mouse prefrontal cortex (PFC), ventromedial (VM) and mediodorsal (MD) thalamic afferents target distinct sub-layers of layer 1 and engage non-overlapping interneuron classes: VM excites NDNF+ cells in L1a (which inhibit L5 PT apical dendrites and selectively suppress VM-evoked apical Ca²⁺ spikes), while MD excites VIP+ cells in L1b — producing parallel rather than convergent feed-forward L1 inhibitory circuits.",
  "cite_key": "Anastasiades2021",
  "evidence": "Anatomical tracing, ChR2-assisted optogenetics, whole-cell recordings and two-photon Ca²⁺ imaging of NDNF+ and VIP+ L1 interneurons and L5 PT pyramids in mouse PFC slices.",
  "effect_size": "qualitative — segregated VM-NDNF (L1a) vs MD-VIP (L1b) targeting in PFC L1",
  "text_access": "fulltext",
  "study_system": "mouse prefrontal cortex layer 1, L5 PT and NDNF+/VIP+ interneurons",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "VM engages NDNF+ cells in L1a, and MD drives VIP+ cells in L1b. These separate populations of L1 interneurons participate in different inhibitory networks in superficial layers by targeting either PV+ or SOM+ interneurons",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.1016/j.neuron.2018.03.024"
  ],
  "effect_size_source_sentence": "VM engages NDNF+ cells in L1a, and MD drives VIP+ cells in L1b"
}

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]

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