Version history

{
  "scope": "mouse hippocampus CA1; in vivo + computational",
  "claim_text": "In hippocampal CA1, VIP+ interneurons are heterogeneous: ~48% co-express calretinin (interneuron-targeting) and ~8% co-express CCK (perisomatic basket cells targeting pyramids); optogenetic activation of VIP+ cells produces net disinhibition of CA1 pyramidal cells, and monosynaptic rabies tracing reveals long-range inputs that may convey reward-related signals.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.neuron.2019.01.009",
    "claim": "In hippocampal CA1, VIP+ interneurons are heterogeneous: ~48% co-express calretinin (interneuron-targeting) and ~8% co-express CCK (perisomatic basket cells targeting pyramids); optogenetic activation of VIP+ cells produces net disinhibition of CA1 pyramidal cells, and monosynaptic rabies tracing reveals long-range inputs that may convey reward-related signals.",
    "title": null,
    "cite_key": "Turi2019",
    "evidence": "Optogenetic activation/silencing in VIP-IRES-Cre mice during behavior; in vivo Ca2+ imaging; monosynaptic rabies; computational modeling.",
    "effect_size": "~53% of VIP+ INs in CA1 stratum pyramidale; CR-co-express 48%, CCK-co-express 8%",
    "text_access": "fulltext",
    "study_system": "mouse hippocampus CA1; in vivo + computational",
    "_source_cluster": "cluster_05_synaptic_connectivity",
    "replication_status": "replicated",
    "_source_cluster_index": 14,
    "claim_source_sentence": "We focused on VIP+ INs in the CA1 stratum pyramidale , where the majority (53%) of these INs are located and identifiable as IN-targeting based on high level of calretinin (CR) (48%) and low level of cholecystokinin (CCK) co-expression (8%) ( ) ( ; ; ; ).",
    "replication_evidence_dois": [
      "10.1523/jneurosci.16-10-03397.1996"
    ],
    "effect_size_source_sentence": "where the majority (53%) of these INs are located and identifiable as IN-targeting based on high level of calretinin (CR) (48%) and low level of cholecystokinin (CCK) co-expression (8%)"
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "effect_size": "~53% of VIP+ INs in CA1 stratum pyramidale; CR-co-express 48%, CCK-co-express 8%",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-c0f52ec4cd1c"
  ],
  "source_span": "We focused on VIP+ INs in the CA1 stratum pyramidale , where the majority (53%) of these INs are located and identifiable as IN-targeting based on high level of calretinin (CR) (48%) and low level of cholecystokinin (CCK) co-expression (8%) ( ) ( ; ; ; ).",
  "study_system": "mouse hippocampus CA1; in vivo + computational",
  "evidence_refs": [
    {
      "ref": "paper:paper-c0f52ec4cd1c"
    }
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Optogenetic activation/silencing in VIP-IRES-Cre mice during behavior; in vivo Ca2+ imaging; monosynaptic rabies; computational modeling.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}