- claim_text
In hippocampal CA1, VIP+ interneurons are heterogeneous: ~48% co-express calretinin (interneuron-targeting) and ~8% co-express CCK (perisomatic basket cells targeting pyramids); optogenetic activation of VIP+ cells produces net disinhibition of CA1 pyramidal cells, and monosynaptic rabies tracing reveals long-range inputs that may convey reward-related signals.
- raw_fields
{
"n": null,
"doi": "10.1016/j.neuron.2019.01.009",
"claim": "In hippocampal CA1, VIP+ interneurons are heterogeneous: ~48% co-express calretinin (interneuron-targeting) and ~8% co-express CCK (perisomatic basket cells targeting pyramids); optogenetic activation of VIP+ cells produces net disinhibition of CA1 pyramidal cells, and monosynaptic rabies tracing reveals long-range inputs that may convey reward-related signals.",
"title": null,
"cite_key": "Turi2019",
"evidence": "Optogenetic activation/silencing in VIP-IRES-Cre mice during behavior; in vivo Ca2+ imaging; monosynaptic rabies; computational modeling.",
"effect_size": "~53% of VIP+ INs in CA1 stratum pyramidale; CR-co-express 48%, CCK-co-express 8%",
"text_access": "fulltext",
"study_system": "mouse hippocampus CA1; in vivo + computational",
"_source_cluster": "cluster_05_synaptic_connectivity",
"replication_status": "replicated",
"_source_cluster_index": 14,
"claim_source_sentence": "We focused on VIP+ INs in the CA1 stratum pyramidale , where the majority (53%) of these INs are located and identifiable as IN-targeting based on high level of calretinin (CR) (48%) and low level of cholecystokinin (CCK) co-expression (8%) ( ) ( ; ; ; ).",
"replication_evidence_dois": [
"10.1523/jneurosci.16-10-03397.1996"
],
"effect_size_source_sentence": "where the majority (53%) of these INs are located and identifiable as IN-targeting based on high level of calretinin (CR) (48%) and low level of cholecystokinin (CCK) co-expression (8%)"
}- source_refs
[
"paper:paper-c0f52ec4cd1c"
]
- source_span
We focused on VIP+ INs in the CA1 stratum pyramidale , where the majority (53%) of these INs are located and identifiable as IN-targeting based on high level of calretinin (CR) (48%) and low level of cholecystokinin (CCK) co-expression (8%) ( ) ( ; ; ; ).
- evidence_refs
[
{
"ref": "paper:paper-c0f52ec4cd1c"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}