In V1, SOM interneurons fire over a wide ACh concentration range (1 μM–10 mM) w…

In V1, SOM interneurons fire over a wide ACh concentration range (1 μM–10 mM) while VIP and L1 interneurons only depolarize at ≥100 μM ACh and fire at 10 mM; SOM neurons indirectly inhibit VIP/L1 via interneuron-specific connections, suggesting that VIP/L1 cholinergic activation requires SOM disinhibition or higher ACh concentrations.

{
  "n": null,
  "doi": "10.1038/nn.4002",
  "claim": "In V1, SOM interneurons fire over a wide ACh concentration range (1 μM–10 mM) while VIP and L1 interneurons only depolarize at ≥100 μM ACh and fire at 10 mM; SOM neurons indirectly inhibit VIP/L1 via interneuron-specific connections, suggesting that VIP/L1 cholinergic activation requires SOM disinhibition or higher ACh concentrations.",
  "title": null,
  "cite_key": "Chen2015a",
  "evidence": "Slice whole-cell recordings from SOM/VIP/L1 with bath-applied ACh; optogenetic Arch silencing of SOM in awake mice.",
  "effect_size": "ACh dose-response: SOM 1 μM–10 mM, VIP 100 μM–10 mM",
  "text_access": "fulltext",
  "study_system": "mouse V1 slice + in vivo",
  "_source_cluster": "cluster_05_synaptic_connectivity",
  "replication_status": "replicated",
  "_source_cluster_index": 9,
  "claim_source_sentence": "Interestingly, SOM neurons fired robustly to a wide range of ACh concentrations (1 μM – 10 mM), consistent with their low threshold spiking properties ( ) , while VIP and L1 neurons depolarized at 100 μM ACh but fired only at 10 mM ACh ( : Example responses evoked by 100 μM ACh ; ).",
  "replication_evidence_dois": [
    "10.1523/jneurosci.19-13-05228.1999"
  ],
  "effect_size_source_sentence": "Interestingly, SOM neurons fired robustly to a wide range of ACh concentrations (1 μM – 10 mM), consistent with their low threshold spiking properties ( ) , while VIP and L1 neurons depolarized at 100 μM ACh but fired only at 10 mM ACh"
}

[
  "paper:paper-2c3589e2f07a"
]

Interestingly, SOM neurons fired robustly to a wide range of ACh concentrations (1 μM – 10 mM), consistent with their low threshold spiking properties ( ) , while VIP and L1 neurons depolarized at 100 μM ACh but fired only at 10 mM ACh ( : Example responses evoked by 100 μM ACh ; ).

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    "ref": "paper:paper-2c3589e2f07a"
  }
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  "notes": [
    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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