Version history

{
  "scope": "mouse V1 slice + in vivo",
  "claim_text": "In V1, SOM interneurons fire over a wide ACh concentration range (1 μM–10 mM) while VIP and L1 interneurons only depolarize at ≥100 μM ACh and fire at 10 mM; SOM neurons indirectly inhibit VIP/L1 via interneuron-specific connections, suggesting that VIP/L1 cholinergic activation requires SOM disinhibition or higher ACh concentrations.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/nn.4002",
    "claim": "In V1, SOM interneurons fire over a wide ACh concentration range (1 μM–10 mM) while VIP and L1 interneurons only depolarize at ≥100 μM ACh and fire at 10 mM; SOM neurons indirectly inhibit VIP/L1 via interneuron-specific connections, suggesting that VIP/L1 cholinergic activation requires SOM disinhibition or higher ACh concentrations.",
    "title": null,
    "cite_key": "Chen2015a",
    "evidence": "Slice whole-cell recordings from SOM/VIP/L1 with bath-applied ACh; optogenetic Arch silencing of SOM in awake mice.",
    "effect_size": "ACh dose-response: SOM 1 μM–10 mM, VIP 100 μM–10 mM",
    "text_access": "fulltext",
    "study_system": "mouse V1 slice + in vivo",
    "_source_cluster": "cluster_05_synaptic_connectivity",
    "replication_status": "replicated",
    "_source_cluster_index": 9,
    "claim_source_sentence": "Interestingly, SOM neurons fired robustly to a wide range of ACh concentrations (1 μM – 10 mM), consistent with their low threshold spiking properties ( ) , while VIP and L1 neurons depolarized at 100 μM ACh but fired only at 10 mM ACh ( : Example responses evoked by 100 μM ACh ; ).",
    "replication_evidence_dois": [
      "10.1523/jneurosci.19-13-05228.1999"
    ],
    "effect_size_source_sentence": "Interestingly, SOM neurons fired robustly to a wide range of ACh concentrations (1 μM – 10 mM), consistent with their low threshold spiking properties ( ) , while VIP and L1 neurons depolarized at 100 μM ACh but fired only at 10 mM ACh"
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "effect_size": "ACh dose-response: SOM 1 μM–10 mM, VIP 100 μM–10 mM",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-2c3589e2f07a"
  ],
  "source_span": "Interestingly, SOM neurons fired robustly to a wide range of ACh concentrations (1 μM – 10 mM), consistent with their low threshold spiking properties ( ) , while VIP and L1 neurons depolarized at 100 μM ACh but fired only at 10 mM ACh ( : Example responses evoked by 100 μM ACh ; ).",
  "study_system": "mouse V1 slice + in vivo",
  "evidence_refs": [
    {
      "ref": "paper:paper-2c3589e2f07a"
    }
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Slice whole-cell recordings from SOM/VIP/L1 with bath-applied ACh; optogenetic Arch silencing of SOM in awake mice.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}