Newly developed genetically encoded voltage indicators, including SomArchon, Qu…

Newly developed genetically encoded voltage indicators, including SomArchon, QuasAr3, Voltron, ASAP3, and Ace2N, can capture individual action potentials in behaving mice, with digital-micromirror-device targeted illumination further increasing signal contrast and reducing background cross-contamination for widefield voltage imaging of tens of neurons.

{
  "n": 0,
  "doi": "10.1016/j.isci.2021.103263",
  "claim": "Newly developed genetically encoded voltage indicators, including SomArchon, QuasAr3, Voltron, ASAP3, and Ace2N, can capture individual action potentials in behaving mice, with digital-micromirror-device targeted illumination further increasing signal contrast and reducing background cross-contamination for widefield voltage imaging of tens of neurons.",
  "cite_key": "Xiao2021",
  "evidence": "Demonstrates the present capability of in vivo voltage imaging in mouse cortex and the role of targeted illumination — directly relevant to cluster_14 voltage-imaging methodological scope.",
  "effect_size": "Simultaneous imaging of tens of spiking neurons over minutes in behaving mice",
  "text_access": "fulltext",
  "study_system": "Behaving mouse cortex; widefield voltage imaging with SomArchon and targeted illumination",
  "argument_role": "supporting",
  "replication_status": "replicated",
  "claim_source_sentence": "In particular, a few newly developed GEVIs, including SomArchon, QuasAr3, Voltron, ASAP3, and Ace2N, have been shown to be able to capture individual action potentials in behaving mice.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.1038/s41592-024-02275-w",
    "10.1038/s41467-024-49192-2"
  ],
  "effect_size_source_sentence": "With the use of a high-speed, large-area sCMOS camera, we routinely imaged tens of spiking neurons simultaneously over minutes in behaving mice."
}

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15. Methodological limits and emerging tools — what current mouse-cortex tools cannot yet measure about E→E recurrence (subthreshold network activity, fast plasticity in vivo, millimetre-scale dynamic connectomes), and what is on the near horizon

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