Version history

{
  "scope": "Behaving mouse cortex; widefield voltage imaging with SomArchon and targeted illumination",
  "claim_text": "Newly developed genetically encoded voltage indicators, including SomArchon, QuasAr3, Voltron, ASAP3, and Ace2N, can capture individual action potentials in behaving mice, with digital-micromirror-device targeted illumination further increasing signal contrast and reducing background cross-contamination for widefield voltage imaging of tens of neurons.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.isci.2021.103263",
    "claim": "Newly developed genetically encoded voltage indicators, including SomArchon, QuasAr3, Voltron, ASAP3, and Ace2N, can capture individual action potentials in behaving mice, with digital-micromirror-device targeted illumination further increasing signal contrast and reducing background cross-contamination for widefield voltage imaging of tens of neurons.",
    "cite_key": "Xiao2021",
    "evidence": "Demonstrates the present capability of in vivo voltage imaging in mouse cortex and the role of targeted illumination — directly relevant to cluster_14 voltage-imaging methodological scope.",
    "effect_size": "Simultaneous imaging of tens of spiking neurons over minutes in behaving mice",
    "text_access": "fulltext",
    "study_system": "Behaving mouse cortex; widefield voltage imaging with SomArchon and targeted illumination",
    "argument_role": "supporting",
    "replication_status": "replicated",
    "claim_source_sentence": "In particular, a few newly developed GEVIs, including SomArchon, QuasAr3, Voltron, ASAP3, and Ace2N, have been shown to be able to capture individual action potentials in behaving mice.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1038/s41592-024-02275-w",
      "10.1038/s41467-024-49192-2"
    ],
    "effect_size_source_sentence": "With the use of a high-speed, large-area sCMOS camera, we routinely imaged tens of spiking neurons simultaneously over minutes in behaving mice."
  },
  "section_id": "section_15",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_15_evidence_package.json",
  "effect_size": "Simultaneous imaging of tens of spiking neurons over minutes in behaving mice",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-15-methods-limits",
  "source_kind": "review_finding",
  "source_path": "evidence/section_15_evidence_package.json",
  "source_refs": [
    "paper:paper-11a076817784"
  ],
  "source_span": "In particular, a few newly developed GEVIs, including SomArchon, QuasAr3, Voltron, ASAP3, and Ace2N, have been shown to be able to capture individual action potentials in behaving mice.",
  "study_system": "Behaving mouse cortex; widefield voltage imaging with SomArchon and targeted illumination",
  "evidence_refs": [
    {
      "ref": "paper:paper-11a076817784"
    }
  ],
  "section_title": "15. Methodological limits and emerging tools — what current mouse-cortex tools cannot yet measure about E→E recurrence (subthreshold network activity, fast plasticity in vivo, millimetre-scale dynamic connectomes), and what is on the near horizon",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Demonstrates the present capability of in vivo voltage imaging in mouse cortex and the role of targeted illumination — directly relevant to cluster_14 voltage-imaging methodological scope.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-15-methods-limits",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_15_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}