Version history

{
  "scope": "awake mouse S1 L5 PT vs IT pyramidal neurons during whisker-detection task",
  "claim_text": "In mouse somatosensory cortex (S1), the activation of apical dendrites in L5 pyramidal subcerebrally-projecting (PT) neurons — but not in their cortico-cortically-projecting (IT) neighbors — almost exclusively determines the detection threshold for tactile stimuli, demonstrating that dendritic Ca²⁺ activation in the PT subclass is the causal link between cortex and perception via descending interactions with higher-order thalamus, superior colliculus and striatum.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/s41593-020-0677-8",
    "claim": "In mouse somatosensory cortex (S1), the activation of apical dendrites in L5 pyramidal subcerebrally-projecting (PT) neurons — but not in their cortico-cortically-projecting (IT) neighbors — almost exclusively determines the detection threshold for tactile stimuli, demonstrating that dendritic Ca²⁺ activation in the PT subclass is the causal link between cortex and perception via descending interactions with higher-order thalamus, superior colliculus and striatum.",
    "cite_key": "Takahashi2020",
    "evidence": "In-vivo dendritic Ca²⁺ imaging combined with optogenetic dendritic perturbation in transgenic mouse lines distinguishing L5 PT and L5 IT subclasses during a tactile-detection task.",
    "effect_size": "qualitative — PT-only dendritic Ca²⁺ event causally drives perceptual threshold",
    "text_access": "abstract_only",
    "study_system": "awake mouse S1 L5 PT vs IT pyramidal neurons during whisker-detection task",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "the activation of apical dendrites in neurons of the somatosensory cortex, which project to subcortical regions, almost exclusively determined the detection of tactile stimuli in mice",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1126/science.aah6066"
    ],
    "effect_size_source_sentence": "almost exclusively determined the detection of tactile stimuli in mice"
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "effect_size": "qualitative — PT-only dendritic Ca²⁺ event causally drives perceptual threshold",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-7a17e6b19058"
  ],
  "source_span": "the activation of apical dendrites in neurons of the somatosensory cortex, which project to subcortical regions, almost exclusively determined the detection of tactile stimuli in mice",
  "study_system": "awake mouse S1 L5 PT vs IT pyramidal neurons during whisker-detection task",
  "evidence_refs": [
    {
      "ref": "paper:paper-7a17e6b19058"
    }
  ],
  "section_title": "7. Cell-type-specific E→E motifs in mouse — IT vs PT vs CT pyramidal projection classes; L5 thick-tufted recurrence; Patch-seq and Allen mouse-cortex taxonomy intersections; transcriptomic-type-specific connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "In-vivo dendritic Ca²⁺ imaging combined with optogenetic dendritic perturbation in transgenic mouse lines distinguishing L5 PT and L5 IT subclasses during a tactile-detection task.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}