In mouse somatosensory cortex (S1), the activation of apical dendrites in L5 py…

In mouse somatosensory cortex (S1), the activation of apical dendrites in L5 pyramidal subcerebrally-projecting (PT) neurons — but not in their cortico-cortically-projecting (IT) neighbors — almost exclusively determines the detection threshold for tactile stimuli, demonstrating that dendritic Ca²⁺ activation in the PT subclass is the causal link between cortex and perception via descending interactions with higher-order thalamus, superior colliculus and striatum.

{
  "n": 0,
  "doi": "10.1038/s41593-020-0677-8",
  "claim": "In mouse somatosensory cortex (S1), the activation of apical dendrites in L5 pyramidal subcerebrally-projecting (PT) neurons — but not in their cortico-cortically-projecting (IT) neighbors — almost exclusively determines the detection threshold for tactile stimuli, demonstrating that dendritic Ca²⁺ activation in the PT subclass is the causal link between cortex and perception via descending interactions with higher-order thalamus, superior colliculus and striatum.",
  "cite_key": "Takahashi2020",
  "evidence": "In-vivo dendritic Ca²⁺ imaging combined with optogenetic dendritic perturbation in transgenic mouse lines distinguishing L5 PT and L5 IT subclasses during a tactile-detection task.",
  "effect_size": "qualitative — PT-only dendritic Ca²⁺ event causally drives perceptual threshold",
  "text_access": "abstract_only",
  "study_system": "awake mouse S1 L5 PT vs IT pyramidal neurons during whisker-detection task",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "the activation of apical dendrites in neurons of the somatosensory cortex, which project to subcortical regions, almost exclusively determined the detection of tactile stimuli in mice",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1126/science.aah6066"
  ],
  "effect_size_source_sentence": "almost exclusively determined the detection of tactile stimuli in mice"
}

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