Version history

{
  "scope": "Mouse barrel cortex; sCRACM circuit mapping.",
  "claim_text": "Subcellular ChR2-assisted circuit mapping (sCRACM) in mouse barrel cortex shows that callosal/cortico-cortical excitatory inputs onto identified pyramidal neurons target specific dendritic domains distinct from local and thalamocortical inputs, providing direct evidence that cortico-cortical synapses are subcellularly segregated.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/nature07709",
    "claim": "Subcellular ChR2-assisted circuit mapping (sCRACM) in mouse barrel cortex shows that callosal/cortico-cortical excitatory inputs onto identified pyramidal neurons target specific dendritic domains distinct from local and thalamocortical inputs, providing direct evidence that cortico-cortical synapses are subcellularly segregated.",
    "cite_key": "Petreanu2009",
    "evidence": "ChR2 expression in two thalamic nuclei, whisker motor cortex, and local excitatory neurons in mouse barrel cortex + whole-cell patch + sCRACM mapping.",
    "effect_size": "Long-range cortico-cortical inputs from M1 occupy distinct dendritic compartments from local inputs and thalamocortical inputs on barrel cortex pyramidal cells.",
    "text_access": "abstract_only",
    "study_system": "Mouse barrel cortex; sCRACM circuit mapping.",
    "argument_role": "supporting",
    "replication_status": "replicated",
    "claim_source_sentence": "Here we developed an efficient channelrhodopsin-2 (ChR2)-assisted method to map the spatial distribution of synaptic inputs, defined by presynaptic ChR2 expression, within the dendritic arborizations of recorded neurons.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2011.07.029"
    ],
    "effect_size_source_sentence": "The dendrites of individual cortical neurons overlap with numerous types of local and long-range excitatory axons, but axodendritic overlap is not always a good predictor of actual connection strength."
  },
  "section_id": "section_08",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "effect_size": "Long-range cortico-cortical inputs from M1 occupy distinct dendritic compartments from local inputs and thalamocortical inputs on barrel cortex pyramidal cells.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:914d374f-2785-4b45-b1ed-71edc0641508"
  ],
  "source_span": "Here we developed an efficient channelrhodopsin-2 (ChR2)-assisted method to map the spatial distribution of synaptic inputs, defined by presynaptic ChR2 expression, within the dendritic arborizations of recorded neurons.",
  "study_system": "Mouse barrel cortex; sCRACM circuit mapping.",
  "evidence_refs": [
    {
      "ref": "paper:914d374f-2785-4b45-b1ed-71edc0641508"
    }
  ],
  "section_title": "8. Cross-areal mouse cortico-cortical excitatory connectivity — hierarchical feedforward and feedback as recurrent loops at the network level; Allen Mouse Connectivity Atlas anchored views",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "ChR2 expression in two thalamic nuclei, whisker motor cortex, and local excitatory neurons in mouse barrel cortex + whole-cell patch + sCRACM mapping.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}