Details
- scope
- mouse, embryonic GE → adult cortex fate mapping
- section_id
- section_03
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json
- effect_size
- Near-complete (≈100%) overlap of Mash1-CreER fate-map with 5HT3aR+ cortical interneurons
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-03-development
- source_kind
- review_finding
- source_path
- evidence/section_03_evidence_package.json
- source_span
- The second strategy used the L/CGE-specific Mash1-BAC CreER ; R26R tdRFP mouse line showing a nearly complete overlap with 5HT3aR cells confirming the CGE as the major source of this population.
- study_system
- mouse, embryonic GE → adult cortex fate mapping
- section_title
- Developmental Origins and Postnatal Maturation
- evidence_summary
- GIFM (genetic inducible fate mapping) using Mash1-BAC CreER × R26R tdRFP cross; complementary Nkx2.1-BAC cre experiment showed no overlap with 5HT3aR cells, excluding MGE.
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- review
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-03-development
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- claim_text
Genetic inducible fate mapping with the L/CGE-specific Mash1-BAC CreER mouse line shows nearly complete overlap with 5HT3aR-expressing cortical interneurons, confirming the CGE as the major embryonic source of cortical 5HT3aR/VIP-lineage interneurons.
- raw_fields
{ "n": null, "doi": "10.1002/dneu.20853", "claim": "Genetic inducible fate mapping with the L/CGE-specific Mash1-BAC CreER mouse line shows nearly complete overlap with 5HT3aR-expressing cortical interneurons, confirming the CGE as the major embryonic source of cortical 5HT3aR/VIP-lineage interneurons.", "title": null, "cite_key": "Rudy2011", "evidence": "GIFM (genetic inducible fate mapping) using Mash1-BAC CreER × R26R tdRFP cross; complementary Nkx2.1-BAC cre experiment showed no overlap with 5HT3aR cells, excluding MGE.", "effect_size": "Near-complete (≈100%) overlap of Mash1-CreER fate-map with 5HT3aR+ cortical interneurons", "figure_data": [], "text_access": "fulltext", "study_system": "mouse, embryonic GE → adult cortex fate mapping", "_source_cluster": "cluster_02_development_lineage", "replication_status": "review", "_source_cluster_index": 89, "claim_source_sentence": "The second strategy used the L/CGE-specific Mash1-BAC CreER ; R26R tdRFP mouse line showing a nearly complete overlap with 5HT3aR cells confirming the CGE as the major source of this population.", "replication_evidence_dois": [ "10.1523/jneurosci.1869-10.2010" ], "effect_size_source_sentence": "The second strategy used the L/CGE-specific Mash1-BAC CreER ; R26R tdRFP mouse line showing a nearly complete overlap with 5HT3aR cells confirming the CGE as the major source of this population." }- source_refs
[ "paper:34a07597-2d6f-4552-b9cf-d2d11817f9f9" ]
- evidence_refs
[ { "ref": "paper:34a07597-2d6f-4552-b9cf-d2d11817f9f9" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }