Developmental Origins and Postnatal Maturation

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^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference} Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...
^{2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference} Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...
^{3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference} Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...
^{2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference} Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...
^{4Citationpaper:paper-723f84ba97fdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference} Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}0 Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}1. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}2 Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}3. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}4 Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}5. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}6 Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}7. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}8 Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}9. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...
^{2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}0 Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses ^{2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}1. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...
^{2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}2 Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses ^{2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}3. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...
^{2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}4 Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses ^{2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}5. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...
^{2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}6 Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses ^{2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}7. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...
^{2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}8 Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses ^{2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}9. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}0 The mapping of GABAergic subtypes onto subpallial origins is one of the most extensively replicated facts in cortical development. Homochronic transplantation of medial-ganglionic-eminence (MGE) versus caudal-ganglionic-eminence (CGE) explants into host mouse embryos established that PV and SST cardinal classes derive primarily from the MGE, whereas reelin-, calretinin-, NPY- and VIP-expressing cardinal classes deri...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}1 The mapping of GABAergic subtypes onto subpallial origins is one of the most extensively replicated facts in cortical development. Homochronic transplantation of medial-ganglionic-eminence (MGE) versus caudal-ganglionic-eminence (CGE) explants into host mouse embryos established that PV and SST cardinal classes derive primarily from the MGE, whereas reelin-, calretinin-, NPY- and VIP-expressing cardinal classes deri...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}2 The mapping of GABAergic subtypes onto subpallial origins is one of the most extensively replicated facts in cortical development. Homochronic transplantation of medial-ganglionic-eminence (MGE) versus caudal-ganglionic-eminence (CGE) explants into host mouse embryos established that PV and SST cardinal classes derive primarily from the MGE, whereas reelin-, calretinin-, NPY- and VIP-expressing cardinal classes deri...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}3 Within this CGE-derived population, the serotonin 5-HT3A receptor (encoded by Htr3a) provides a near-complete molecular handle. ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}4 showed that 5-HT3AR expression demarcates essentially all neocortical GABAergic interneurons that lack PV/SST and labels the entire CGE lineage in mouse cortex ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}5. Homochronic in utero grafts of E14 Htr3a-GFP+ cells into host cortex reproduce the supragranular laminar b...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}6 Within this CGE-derived population, the serotonin 5-HT3A receptor (encoded by Htr3a) provides a near-complete molecular handle. ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}7 showed that 5-HT3AR expression demarcates essentially all neocortical GABAergic interneurons that lack PV/SST and labels the entire CGE lineage in mouse cortex ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}8. Homochronic in utero grafts of E14 Htr3a-GFP+ cells into host cortex reproduce the supragranular laminar b...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}9 Within this CGE-derived population, the serotonin 5-HT3A receptor (encoded by Htr3a) provides a near-complete molecular handle. ^{3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}0 showed that 5-HT3AR expression demarcates essentially all neocortical GABAergic interneurons that lack PV/SST and labels the entire CGE lineage in mouse cortex ^{3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}1. Homochronic in utero grafts of E14 Htr3a-GFP+ cells into host cortex reproduce the supragranular laminar b...
^{3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}2 Within this CGE-derived population, the serotonin 5-HT3A receptor (encoded by Htr3a) provides a near-complete molecular handle. ^{3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}3 showed that 5-HT3AR expression demarcates essentially all neocortical GABAergic interneurons that lack PV/SST and labels the entire CGE lineage in mouse cortex ^{3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}4. Homochronic in utero grafts of E14 Htr3a-GFP+ cells into host cortex reproduce the supragranular laminar b...
^{3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}5 Within this CGE-derived population, the serotonin 5-HT3A receptor (encoded by Htr3a) provides a near-complete molecular handle. ^{3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}6 showed that 5-HT3AR expression demarcates essentially all neocortical GABAergic interneurons that lack PV/SST and labels the entire CGE lineage in mouse cortex ^{3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}7. Homochronic in utero grafts of E14 Htr3a-GFP+ cells into host cortex reproduce the supragranular laminar b...
^{3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}8 Two clarifications are needed. First, the CGE is not the only ventral source of cortical inhibitory cells: the embryonic preoptic area (POA) generates a smaller, mostly reelin+ population that contributes to layer-1 NGC-like cells and that — because POA-derived cells share PROX1, NR2F2 and reelin expression with CGE-derived NGCs — partially confounds CGE-only fate maps ^{3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}9. Second, the dorsal M...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}0 Two clarifications are needed. First, the CGE is not the only ventral source of cortical inhibitory cells: the embryonic preoptic area (POA) generates a smaller, mostly reelin+ population that contributes to layer-1 NGC-like cells and that — because POA-derived cells share PROX1, NR2F2 and reelin expression with CGE-derived NGCs — partially confounds CGE-only fate maps ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}1. Second, the dorsal M...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}2 ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}3 and Prior work ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}4 placed cortical NGCs squarely within the CGE-derived 5-HT3AR+ lineage. Earlier reports ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}5 showed that a substantial fraction of cortical NGCs is generated by a 5-HT3AR+ Hmx3+ pool in the preoptic area, expressing PROX1, NR2F2 and reelin but not VIP. Resolution: NGCs are a mixed-origin class with both CGE- and POA-derived contingents that share a 5-HT3AR/PROX1/RELN...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}6 ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}7 and Prior work ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}8 placed cortical NGCs squarely within the CGE-derived 5-HT3AR+ lineage. Earlier reports ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}9 showed that a substantial fraction of cortical NGCs is generated by a 5-HT3AR+ Hmx3+ pool in the preoptic area, expressing PROX1, NR2F2 and reelin but not VIP. Resolution: NGCs are a mixed-origin class with both CGE- and POA-derived contingents that share a 5-HT3AR/PROX1/RELN...
^{2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}0 ^{2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}1 and Prior work ^{2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}2 placed cortical NGCs squarely within the CGE-derived 5-HT3AR+ lineage. Earlier reports ^{2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}3 showed that a substantial fraction of cortical NGCs is generated by a 5-HT3AR+ Hmx3+ pool in the preoptic area, expressing PROX1, NR2F2 and reelin but not VIP. Resolution: NGCs are a mixed-origin class with both CGE- and POA-derived contingents that share a 5-HT3AR/PROX1/RELN...
^{2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}4 The transcription-factor (TF) logic that specifies CGE-derived interneurons differs in detail from the Lhx6/Sox6-dominated MGE programme ^{2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}5. Single-cell transcriptomic profiling of E13.5 MGE and E14.5 CGE/LGE reveals a conserved mitotic-progenitor maturation trajectory across all three eminences, onto which eminence-specific TF cassettes are overlaid in postmitotic precursors to seed cardinal-class div...
^{2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}6 The transcription-factor (TF) logic that specifies CGE-derived interneurons differs in detail from the Lhx6/Sox6-dominated MGE programme ^{2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}7. Single-cell transcriptomic profiling of E13.5 MGE and E14.5 CGE/LGE reveals a conserved mitotic-progenitor maturation trajectory across all three eminences, onto which eminence-specific TF cassettes are overlaid in postmitotic precursors to seed cardinal-class div...
^{2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}8 The transcription-factor (TF) logic that specifies CGE-derived interneurons differs in detail from the Lhx6/Sox6-dominated MGE programme ^{2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}9. Single-cell transcriptomic profiling of E13.5 MGE and E14.5 CGE/LGE reveals a conserved mitotic-progenitor maturation trajectory across all three eminences, onto which eminence-specific TF cassettes are overlaid in postmitotic precursors to seed cardinal-class div...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}0 The transcription-factor (TF) logic that specifies CGE-derived interneurons differs in detail from the Lhx6/Sox6-dominated MGE programme ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}1. Single-cell transcriptomic profiling of E13.5 MGE and E14.5 CGE/LGE reveals a conserved mitotic-progenitor maturation trajectory across all three eminences, onto which eminence-specific TF cassettes are overlaid in postmitotic precursors to seed cardinal-class div...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}2 Among the CGE-class TFs, Prox1 has the strongest causal evidence. PROX1 is expressed in 84% of fate-mapped CGE/LGE/POA-derived interneurons and in 100% of VIP+ cortical interneurons in P30 mouse cortex ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}3, and is selectively maintained in postmitotic CGE-derived interneuron precursors as the first identified CGE-specific postmitotic TF ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}4. Embryonic conditional deletion of Prox1 impairs the...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}5 Among the CGE-class TFs, Prox1 has the strongest causal evidence. PROX1 is expressed in 84% of fate-mapped CGE/LGE/POA-derived interneurons and in 100% of VIP+ cortical interneurons in P30 mouse cortex ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}6, and is selectively maintained in postmitotic CGE-derived interneuron precursors as the first identified CGE-specific postmitotic TF ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}7. Embryonic conditional deletion of Prox1 impairs the...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}8 Among the CGE-class TFs, Prox1 has the strongest causal evidence. PROX1 is expressed in 84% of fate-mapped CGE/LGE/POA-derived interneurons and in 100% of VIP+ cortical interneurons in P30 mouse cortex ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}9, and is selectively maintained in postmitotic CGE-derived interneuron precursors as the first identified CGE-specific postmitotic TF ^{4Citationpaper:paper-723f84ba97fdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}0. Embryonic conditional deletion of Prox1 impairs the...
^{4Citationpaper:paper-723f84ba97fdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}1 Among the CGE-class TFs, Prox1 has the strongest causal evidence. PROX1 is expressed in 84% of fate-mapped CGE/LGE/POA-derived interneurons and in 100% of VIP+ cortical interneurons in P30 mouse cortex ^{4Citationpaper:paper-723f84ba97fdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}2, and is selectively maintained in postmitotic CGE-derived interneuron precursors as the first identified CGE-specific postmitotic TF ^{4Citationpaper:paper-723f84ba97fdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}3. Embryonic conditional deletion of Prox1 impairs the...
^{4Citationpaper:paper-723f84ba97fdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}4 COUP-TFII (NR2F2) is preferentially expressed in CGE relative to MGE and is required for the caudal migratory stream that channels CGE progeny into caudal cortex, hippocampus and amygdala ^{4Citationpaper:paper-723f84ba97fdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}5. In adult mouse cortex, Cai2013 showed that COUP-TFII is also expressed in dorsal MGE-, dorsal LGE- and POA-derived cells, so COUP-TFII positivity is not a clean CGE-only marker ^{4Citationpaper:paper-723f84ba97fdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}6. In hippocampus, COUP-...
^{4Citationpaper:paper-723f84ba97fdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}7 COUP-TFII (NR2F2) is preferentially expressed in CGE relative to MGE and is required for the caudal migratory stream that channels CGE progeny into caudal cortex, hippocampus and amygdala ^{4Citationpaper:paper-723f84ba97fdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}8. In adult mouse cortex, Cai2013 showed that COUP-TFII is also expressed in dorsal MGE-, dorsal LGE- and POA-derived cells, so COUP-TFII positivity is not a clean CGE-only marker ^{4Citationpaper:paper-723f84ba97fdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}9. In hippocampus, COUP-...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}0 COUP-TFII (NR2F2) is preferentially expressed in CGE relative to MGE and is required for the caudal migratory stream that channels CGE progeny into caudal cortex, hippocampus and amygdala ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}1. In adult mouse cortex, Cai2013 showed that COUP-TFII is also expressed in dorsal MGE-, dorsal LGE- and POA-derived cells, so COUP-TFII positivity is not a clean CGE-only marker ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}2. In hippocampus, COUP-...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}3 COUP-TFII (NR2F2) is preferentially expressed in CGE relative to MGE and is required for the caudal migratory stream that channels CGE progeny into caudal cortex, hippocampus and amygdala ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}4. In adult mouse cortex, Cai2013 showed that COUP-TFII is also expressed in dorsal MGE-, dorsal LGE- and POA-derived cells, so COUP-TFII positivity is not a clean CGE-only marker ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}5. In hippocampus, COUP-...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}6 COUP-TFII (NR2F2) is preferentially expressed in CGE relative to MGE and is required for the caudal migratory stream that channels CGE progeny into caudal cortex, hippocampus and amygdala ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}7. In adult mouse cortex, Cai2013 showed that COUP-TFII is also expressed in dorsal MGE-, dorsal LGE- and POA-derived cells, so COUP-TFII positivity is not a clean CGE-only marker ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}8. In hippocampus, COUP-...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}9 COUP-TFII (NR2F2) is preferentially expressed in CGE relative to MGE and is required for the caudal migratory stream that channels CGE progeny into caudal cortex, hippocampus and amygdala ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}00. In adult mouse cortex, Cai2013 showed that COUP-TFII is also expressed in dorsal MGE-, dorsal LGE- and POA-derived cells, so COUP-TFII positivity is not a clean CGE-only marker ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}01. In hippocampus, COUP-...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}02 Sp8 and Sp9 define a second axis of CGE/dLGE specification. Sp8 is expressed in ~20% of adult cortical interneurons derived from both dorsal LGE and dorsal CGE, weakly in MGE mantle but strongly in CGE/dLGE ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}03, and acts cell-autonomously to specify olfactory-bulb and cortical CGE-related lineages. Co-expressed Sp8/Sp9 in the dorsal CGE SVZ jointly drive CGE-derived interneuron specification in part by rep...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}04 Sp8 and Sp9 define a second axis of CGE/dLGE specification. Sp8 is expressed in ~20% of adult cortical interneurons derived from both dorsal LGE and dorsal CGE, weakly in MGE mantle but strongly in CGE/dLGE ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}05, and acts cell-autonomously to specify olfactory-bulb and cortical CGE-related lineages. Co-expressed Sp8/Sp9 in the dorsal CGE SVZ jointly drive CGE-derived interneuron specification in part by rep...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}06 Sp8 and Sp9 define a second axis of CGE/dLGE specification. Sp8 is expressed in ~20% of adult cortical interneurons derived from both dorsal LGE and dorsal CGE, weakly in MGE mantle but strongly in CGE/dLGE ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}07, and acts cell-autonomously to specify olfactory-bulb and cortical CGE-related lineages. Co-expressed Sp8/Sp9 in the dorsal CGE SVZ jointly drive CGE-derived interneuron specification in part by rep...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}08 Sp8 and Sp9 define a second axis of CGE/dLGE specification. Sp8 is expressed in ~20% of adult cortical interneurons derived from both dorsal LGE and dorsal CGE, weakly in MGE mantle but strongly in CGE/dLGE ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}09, and acts cell-autonomously to specify olfactory-bulb and cortical CGE-related lineages. Co-expressed Sp8/Sp9 in the dorsal CGE SVZ jointly drive CGE-derived interneuron specification in part by rep...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}10 Sp8 and Sp9 define a second axis of CGE/dLGE specification. Sp8 is expressed in ~20% of adult cortical interneurons derived from both dorsal LGE and dorsal CGE, weakly in MGE mantle but strongly in CGE/dLGE ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}11, and acts cell-autonomously to specify olfactory-bulb and cortical CGE-related lineages. Co-expressed Sp8/Sp9 in the dorsal CGE SVZ jointly drive CGE-derived interneuron specification in part by rep...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}12 Several additional regulators affect VIP-relevant subsets. Dlx1/Dlx2 and Dlx5/Dlx6 control CGE neurite outgrowth and tangential migration, and selective Dlx1 loss causes subtype-specific reduction of CR+, SST+ and other cortical/hippocampal interneurons ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}13. CXCL12 attracts immature interneurons during tangential migration via CXCR4/CXCR7 streams in subpial and intermediate-zone...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}14 Several additional regulators affect VIP-relevant subsets. Dlx1/Dlx2 and Dlx5/Dlx6 control CGE neurite outgrowth and tangential migration, and selective Dlx1 loss causes subtype-specific reduction of CR+, SST+ and other cortical/hippocampal interneurons ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}15. CXCL12 attracts immature interneurons during tangential migration via CXCR4/CXCR7 streams in subpial and intermediate-zone...
^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}16 Several additional regulators affect VIP-relevant subsets. Dlx1/Dlx2 and Dlx5/Dlx6 control CGE neurite outgrowth and tangential migration, and selective Dlx1 loss causes subtype-specific reduction of CR+, SST+ and other cortical/hippocampal interneurons ^{1Citationpaper:paper-9cfdde391cfdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 2Citationpaper:paper-2379d07993bdCortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference, 3Citationpaper:paper-pm-30382198Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / Adarb2 lineage that also gives rise to the Lamp5, Sncg and Serpinf1 subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...content/03_development.md:line 4Open reference}17. CXCL12 attracts immature interneurons during tangential migration via CXCR4/CXCR7 streams in subpial and intermediate-zone...
... 124 additional anchors in refs_json

References

[Lee2010] paper:paper-9cfdde391cfd “Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / *Adarb2* lineage that also gives rise to the *Lamp5*, *Sncg* and *Serpinf1* subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...”
[Miyoshi2010] paper:paper-2379d07993bd “Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / *Adarb2* lineage that also gives rise to the *Lamp5*, *Sncg* and *Serpinf1* subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...”
[Tasic2018] paper:paper-pm-30382198 “Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / *Adarb2* lineage that also gives rise to the *Lamp5*, *Sncg* and *Serpinf1* subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...”
[Miyoshi2015] paper:paper-723f84ba97fd “Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / *Adarb2* lineage that also gives rise to the *Lamp5*, *Sncg* and *Serpinf1* subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...”
[Lim2018] paper:paper-11e0bb0a904f “Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / *Adarb2* lineage that also gives rise to the *Lamp5*, *Sncg* and *Serpinf1* subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...”
[Demarcogarcia2025] paper:paper-9443bf50a118 “Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / *Adarb2* lineage that also gives rise to the *Lamp5*, *Sncg* and *Serpinf1* subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...”
[Stachniak2021] paper:paper-b5b2bae45f13 “Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / *Adarb2* lineage that also gives rise to the *Lamp5*, *Sncg* and *Serpinf1* subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...”
[Wei2019] paper:paper-1eabf51af471 “Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / *Adarb2* lineage that also gives rise to the *Lamp5*, *Sncg* and *Serpinf1* subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...”
[Kanatani2008] paper:paper-543abe120c27 “Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / *Adarb2* lineage that also gives rise to the *Lamp5*, *Sncg* and *Serpinf1* subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...”
[Hodge2019] paper:paper-pm-31435019 “Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / *Adarb2* lineage that also gives rise to the *Lamp5*, *Sncg* and *Serpinf1* subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...”
[Hansen2013] paper:paper-69ea07a88dc2 “Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / *Adarb2* lineage that also gives rise to the *Lamp5*, *Sncg* and *Serpinf1* subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...”
[Ma2013] paper:paper-d23aa7722aab “Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / *Adarb2* lineage that also gives rise to the *Lamp5*, *Sncg* and *Serpinf1* subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...”
[Marin2025] paper:paper-bb5efd4c161d “Cortical VIP interneurons are members of the caudal-ganglionic-eminence (CGE)–derived 5-HT3AR / *Adarb2* lineage that also gives rise to the *Lamp5*, *Sncg* and *Serpinf1* subclasses [Lee2010,Miyoshi2010,Tasic2018]. The cells are born in a late embryonic neurogenic wave, migrate tangentially along several caudo-rostral streams, settle preferentially in superficial layers, and acquire mature firing, synaptic and morp...”
[Bandler2017] paper:paper-fe53cd98398a “The mapping of GABAergic subtypes onto subpallial origins is one of the most extensively replicated facts in cortical development. Homochronic transplantation of medial-ganglionic-eminence (MGE) versus caudal-ganglionic-eminence (CGE) explants into host mouse embryos established that PV and SST cardinal classes derive primarily from the MGE, whereas reelin-, calretinin-, NPY- and VIP-expressing cardinal classes deri...”
[Mi2018] paper:paper-b95c9d331f47 “The mapping of GABAergic subtypes onto subpallial origins is one of the most extensively replicated facts in cortical development. Homochronic transplantation of medial-ganglionic-eminence (MGE) versus caudal-ganglionic-eminence (CGE) explants into host mouse embryos established that PV and SST cardinal classes derive primarily from the MGE, whereas reelin-, calretinin-, NPY- and VIP-expressing cardinal classes deri...”
[Vucurovic2010] paper:paper-0336a131683f “Within this CGE-derived population, the serotonin 5-HT3A receptor (encoded by *Htr3a*) provides a near-complete molecular handle. [Lee2010] showed that 5-HT3AR expression demarcates essentially all neocortical GABAergic interneurons that lack PV/SST and labels the entire CGE lineage in mouse cortex [Lee2010]. Homochronic in utero grafts of E14 *Htr3a*-GFP+ cells into host cortex reproduce the supragranular laminar b...”
[Gelman2009] paper:paper-e96e4a701dd0 “Two clarifications are needed. First, the CGE is not the only ventral source of cortical inhibitory cells: the embryonic preoptic area (POA) generates a smaller, mostly reelin+ population that contributes to layer-1 NGC-like cells and that — because POA-derived cells share PROX1, NR2F2 and reelin expression with CGE-derived NGCs — partially confounds CGE-only fate maps [Gelman2009,Niquille2018]. Second, the dorsal M...”
[Niquille2018] paper:paper-a4464a65ff38 “Two clarifications are needed. First, the CGE is not the only ventral source of cortical inhibitory cells: the embryonic preoptic area (POA) generates a smaller, mostly reelin+ population that contributes to layer-1 NGC-like cells and that — because POA-derived cells share PROX1, NR2F2 and reelin expression with CGE-derived NGCs — partially confounds CGE-only fate maps [Gelman2009,Niquille2018]. Second, the dorsal M...”
[Liodis2007] paper:paper-835768c03708 “The transcription-factor (TF) logic that specifies CGE-derived interneurons differs in detail from the *Lhx6*/*Sox6*-dominated MGE programme [Liodis2007]. Single-cell transcriptomic profiling of E13.5 MGE and E14.5 CGE/LGE reveals a conserved mitotic-progenitor maturation trajectory across all three eminences, onto which eminence-specific TF cassettes are overlaid in postmitotic precursors to seed cardinal-class div...”
[Mayer2018] paper:paper-c3e9fd7af6d3 “The transcription-factor (TF) logic that specifies CGE-derived interneurons differs in detail from the *Lhx6*/*Sox6*-dominated MGE programme [Liodis2007]. Single-cell transcriptomic profiling of E13.5 MGE and E14.5 CGE/LGE reveals a conserved mitotic-progenitor maturation trajectory across all three eminences, onto which eminence-specific TF cassettes are overlaid in postmitotic precursors to seed cardinal-class div...”
[Allaway2021] paper:paper-1c4a74c94c96 “The transcription-factor (TF) logic that specifies CGE-derived interneurons differs in detail from the *Lhx6*/*Sox6*-dominated MGE programme [Liodis2007]. Single-cell transcriptomic profiling of E13.5 MGE and E14.5 CGE/LGE reveals a conserved mitotic-progenitor maturation trajectory across all three eminences, onto which eminence-specific TF cassettes are overlaid in postmitotic precursors to seed cardinal-class div...”
[Rubin2013] paper:paper-d0d958f4bbd9 “Among the CGE-class TFs, **Prox1** has the strongest causal evidence. PROX1 is expressed in 84% of fate-mapped CGE/LGE/POA-derived interneurons and in 100% of VIP+ cortical interneurons in P30 mouse cortex [Rubin2013], and is selectively maintained in postmitotic CGE-derived interneuron precursors as the first identified CGE-specific postmitotic TF [Miyoshi2015]. Embryonic conditional deletion of *Prox1* impairs the...”
[Cai2013] paper:paper-37e721c1a8c9 “**COUP-TFII (NR2F2)** is preferentially expressed in CGE relative to MGE and is required for the caudal migratory stream that channels CGE progeny into caudal cortex, hippocampus and amygdala [Kanatani2008]. In adult mouse cortex, *Cai2013* showed that COUP-TFII is also expressed in dorsal MGE-, dorsal LGE- and POA-derived cells, so COUP-TFII positivity is not a clean CGE-only marker [Cai2013]. In hippocampus, COUP-...”
[Fuentealba2010] paper:paper-ebfadc446bd4 “**COUP-TFII (NR2F2)** is preferentially expressed in CGE relative to MGE and is required for the caudal migratory stream that channels CGE progeny into caudal cortex, hippocampus and amygdala [Kanatani2008]. In adult mouse cortex, *Cai2013* showed that COUP-TFII is also expressed in dorsal MGE-, dorsal LGE- and POA-derived cells, so COUP-TFII positivity is not a clean CGE-only marker [Cai2013]. In hippocampus, COUP-...”
[Touzot2016] paper:paper-8eefd8cf2890 “**COUP-TFII (NR2F2)** is preferentially expressed in CGE relative to MGE and is required for the caudal migratory stream that channels CGE progeny into caudal cortex, hippocampus and amygdala [Kanatani2008]. In adult mouse cortex, *Cai2013* showed that COUP-TFII is also expressed in dorsal MGE-, dorsal LGE- and POA-derived cells, so COUP-TFII positivity is not a clean CGE-only marker [Cai2013]. In hippocampus, COUP-...”
[Yang2017] paper:paper-e0342c71fcb6 “**COUP-TFII (NR2F2)** is preferentially expressed in CGE relative to MGE and is required for the caudal migratory stream that channels CGE progeny into caudal cortex, hippocampus and amygdala [Kanatani2008]. In adult mouse cortex, *Cai2013* showed that COUP-TFII is also expressed in dorsal MGE-, dorsal LGE- and POA-derived cells, so COUP-TFII positivity is not a clean CGE-only marker [Cai2013]. In hippocampus, COUP-...”
[Reinchisi2012] paper:paper-924449b77fdb “**COUP-TFII (NR2F2)** is preferentially expressed in CGE relative to MGE and is required for the caudal migratory stream that channels CGE progeny into caudal cortex, hippocampus and amygdala [Kanatani2008]. In adult mouse cortex, *Cai2013* showed that COUP-TFII is also expressed in dorsal MGE-, dorsal LGE- and POA-derived cells, so COUP-TFII positivity is not a clean CGE-only marker [Cai2013]. In hippocampus, COUP-...”
[Tao2019] paper:paper-fa8c58248f72 “**Sp8 and Sp9** define a second axis of CGE/dLGE specification. Sp8 is expressed in ~20% of adult cortical interneurons derived from both dorsal LGE and dorsal CGE, weakly in MGE mantle but strongly in CGE/dLGE [Tao2019], and acts cell-autonomously to specify olfactory-bulb and cortical CGE-related lineages. Co-expressed Sp8/Sp9 in the dorsal CGE SVZ jointly drive CGE-derived interneuron specification in part by rep...”
[Liu2019b] paper:paper-855dc9fae473 “**Sp8 and Sp9** define a second axis of CGE/dLGE specification. Sp8 is expressed in ~20% of adult cortical interneurons derived from both dorsal LGE and dorsal CGE, weakly in MGE mantle but strongly in CGE/dLGE [Tao2019], and acts cell-autonomously to specify olfactory-bulb and cortical CGE-related lineages. Co-expressed Sp8/Sp9 in the dorsal CGE SVZ jointly drive CGE-derived interneuron specification in part by rep...”
[Alifragis2004] paper:paper-1ed16c0e2b0a “**Sp8 and Sp9** define a second axis of CGE/dLGE specification. Sp8 is expressed in ~20% of adult cortical interneurons derived from both dorsal LGE and dorsal CGE, weakly in MGE mantle but strongly in CGE/dLGE [Tao2019], and acts cell-autonomously to specify olfactory-bulb and cortical CGE-related lineages. Co-expressed Sp8/Sp9 in the dorsal CGE SVZ jointly drive CGE-derived interneuron specification in part by rep...”
[Zhao2008] paper:paper-ab1ce08cc4c2 “**Sp8 and Sp9** define a second axis of CGE/dLGE specification. Sp8 is expressed in ~20% of adult cortical interneurons derived from both dorsal LGE and dorsal CGE, weakly in MGE mantle but strongly in CGE/dLGE [Tao2019], and acts cell-autonomously to specify olfactory-bulb and cortical CGE-related lineages. Co-expressed Sp8/Sp9 in the dorsal CGE SVZ jointly drive CGE-derived interneuron specification in part by rep...”
[Cobos2007] paper:paper-ac9322a29cee “Several additional regulators affect VIP-relevant subsets. *Dlx1*/*Dlx2* and *Dlx5*/*Dlx6* control CGE neurite outgrowth and tangential migration, and selective *Dlx1* loss causes subtype-specific reduction of CR+, SST+ and other cortical/hippocampal interneurons [Cobos2007,Wang2010,Cobos2005]. CXCL12 attracts immature interneurons during tangential migration via CXCR4/CXCR7 streams in subpial and intermediate-zone...”
[Wang2010] paper:paper-7da1463d66e5 “Several additional regulators affect VIP-relevant subsets. *Dlx1*/*Dlx2* and *Dlx5*/*Dlx6* control CGE neurite outgrowth and tangential migration, and selective *Dlx1* loss causes subtype-specific reduction of CR+, SST+ and other cortical/hippocampal interneurons [Cobos2007,Wang2010,Cobos2005]. CXCL12 attracts immature interneurons during tangential migration via CXCR4/CXCR7 streams in subpial and intermediate-zone...”
[Cobos2005] paper:paper-16db73a8d2a3 “Several additional regulators affect VIP-relevant subsets. *Dlx1*/*Dlx2* and *Dlx5*/*Dlx6* control CGE neurite outgrowth and tangential migration, and selective *Dlx1* loss causes subtype-specific reduction of CR+, SST+ and other cortical/hippocampal interneurons [Cobos2007,Wang2010,Cobos2005]. CXCL12 attracts immature interneurons during tangential migration via CXCR4/CXCR7 streams in subpial and intermediate-zone...”

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