Version history

{
  "scope": "VIP-Cre 5XFAD mouse cortex; chemogenetics + 40-Hz multisensory stimulation; in vivo electrophysiology and amyloid IHC",
  "claim_text": "Chemogenetic inhibition of cortical VIP interneurons attenuates 40-Hz multisensory gamma stimulation–induced amyloid clearance in 5XFAD mice without affecting baseline 40-Hz LFP power, indicating VIP cells couple gamma activity to glymphatic peptide release.",
  "raw_fields": {
    "n": 29,
    "doi": "10.1038/s41586-024-07132-6",
    "pmid": "38418876",
    "year": "2024",
    "claim": "Chemogenetic inhibition of cortical VIP interneurons attenuates 40-Hz multisensory gamma stimulation–induced amyloid clearance in 5XFAD mice without affecting baseline 40-Hz LFP power, indicating VIP cells couple gamma activity to glymphatic peptide release.",
    "pmcid": "PMC10917684",
    "title": "Multisensory gamma stimulation promotes glymphatic clearance of amyloid.",
    "authors": "",
    "journal": "",
    "cite_key": "Murdock2024",
    "evidence": "VIP-Cre × 5XFAD mice with hM4Di-DREADD silencing of VIP cells abolished amyloid clearance benefit of 40-Hz stimulation; no change in baseline 40 Hz power.",
    "cluster_id": "cluster_09_oscillations",
    "effect_size": "n=7-8 mice/group; two-way ANOVA, Fisher's LSD",
    "figure_data": [],
    "text_access": "fulltext",
    "study_system": "VIP-Cre 5XFAD mouse cortex; chemogenetics + 40-Hz multisensory stimulation; in vivo electrophysiology and amyloid IHC",
    "cited_by_count": 275,
    "_source_cluster": "cluster_09_oscillations",
    "replication_status": "single-study",
    "_source_cluster_index": 2,
    "claim_source_sentence": "To causally determine whether VIP interneurons regulate amyloid clearance during gamma stimulation, we chemogenetically inhibited VIP interneurons using PHP.eb.AAV::Syn:DIO-hM4Di-mCherry in VIP-Cre 5XFAD transgenic mice. Chemogenetically inhibiting VIP neurons before gamma stimulation attenuated amyloid clearance (Fig.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Quantification of amyloid in experiment represented in b (n = 7 (no stimulation + tdTomato), 8 (40 Hz + tdTomato), 7 (no stimulation + hM4Di) and 7 (40 Hz + hM4Di) VIP-Cre 5XFAD mice; data are mean ± s.e.m.; P values by two-way ANOVA followed by Fisher's LSD test)."
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "effect_size": "n=7-8 mice/group; two-way ANOVA, Fisher's LSD",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-4e6efd990529"
  ],
  "source_span": "To causally determine whether VIP interneurons regulate amyloid clearance during gamma stimulation, we chemogenetically inhibited VIP interneurons using PHP.eb.AAV::Syn:DIO-hM4Di-mCherry in VIP-Cre 5XFAD transgenic mice. Chemogenetically inhibiting VIP neurons before gamma stimulation attenuated amyloid clearance (Fig.",
  "study_system": "VIP-Cre 5XFAD mouse cortex; chemogenetics + 40-Hz multisensory stimulation; in vivo electrophysiology and amyloid IHC",
  "evidence_refs": [
    {
      "ref": "paper:paper-4e6efd990529"
    }
  ],
  "section_title": "Oscillatory Dynamics and Temporal Coordination",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "VIP-Cre × 5XFAD mice with hM4Di-DREADD silencing of VIP cells abolished amyloid clearance benefit of 40-Hz stimulation; no change in baseline 40 Hz power.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}