Chemogenetic inhibition of cortical VIP interneurons attenuates 40-Hz multisens…

Chemogenetic inhibition of cortical VIP interneurons attenuates 40-Hz multisensory gamma stimulation–induced amyloid clearance in 5XFAD mice without affecting baseline 40-Hz LFP power, indicating VIP cells couple gamma activity to glymphatic peptide release.

{
  "n": 29,
  "doi": "10.1038/s41586-024-07132-6",
  "pmid": "38418876",
  "year": "2024",
  "claim": "Chemogenetic inhibition of cortical VIP interneurons attenuates 40-Hz multisensory gamma stimulation–induced amyloid clearance in 5XFAD mice without affecting baseline 40-Hz LFP power, indicating VIP cells couple gamma activity to glymphatic peptide release.",
  "pmcid": "PMC10917684",
  "title": "Multisensory gamma stimulation promotes glymphatic clearance of amyloid.",
  "authors": "",
  "journal": "",
  "cite_key": "Murdock2024",
  "evidence": "VIP-Cre × 5XFAD mice with hM4Di-DREADD silencing of VIP cells abolished amyloid clearance benefit of 40-Hz stimulation; no change in baseline 40 Hz power.",
  "cluster_id": "cluster_09_oscillations",
  "effect_size": "n=7-8 mice/group; two-way ANOVA, Fisher's LSD",
  "figure_data": [],
  "text_access": "fulltext",
  "study_system": "VIP-Cre 5XFAD mouse cortex; chemogenetics + 40-Hz multisensory stimulation; in vivo electrophysiology and amyloid IHC",
  "cited_by_count": 275,
  "_source_cluster": "cluster_09_oscillations",
  "replication_status": "single-study",
  "_source_cluster_index": 2,
  "claim_source_sentence": "To causally determine whether VIP interneurons regulate amyloid clearance during gamma stimulation, we chemogenetically inhibited VIP interneurons using PHP.eb.AAV::Syn:DIO-hM4Di-mCherry in VIP-Cre 5XFAD transgenic mice. Chemogenetically inhibiting VIP neurons before gamma stimulation attenuated amyloid clearance (Fig.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Quantification of amyloid in experiment represented in b (n = 7 (no stimulation + tdTomato), 8 (40 Hz + tdTomato), 7 (no stimulation + hM4Di) and 7 (40 Hz + hM4Di) VIP-Cre 5XFAD mice; data are mean ± s.e.m.; P values by two-way ANOVA followed by Fisher's LSD test)."
}

[
  "paper:paper-4e6efd990529"
]

To causally determine whether VIP interneurons regulate amyloid clearance during gamma stimulation, we chemogenetically inhibited VIP interneurons using PHP.eb.AAV::Syn:DIO-hM4Di-mCherry in VIP-Cre 5XFAD transgenic mice. Chemogenetically inhibiting VIP neurons before gamma stimulation attenuated amyloid clearance (Fig.

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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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