Version history

{
  "scope": "Mouse, ACA→VISp and ORB→VISp feedback projections; two-photon imaging + chemogenetics",
  "claim_text": "Anterior cingulate and orbitofrontal feedback projections to mouse V1 have dissociable functional roles: ACA input enhances visual encoding and scales with arousal, while ORB input reduces high-contrast visual encoding.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.neuron.2025.10.037",
    "claim": "Anterior cingulate and orbitofrontal feedback projections to mouse V1 have dissociable functional roles: ACA input enhances visual encoding and scales with arousal, while ORB input reduces high-contrast visual encoding.",
    "cite_key": "AhrlundRichter2026",
    "evidence": "Axonal tracing, two-photon calcium imaging, and chemogenetic manipulations in mice comparing ACA and ORB inputs to VISp.",
    "effect_size": "ACA carries stronger visual-stimulus information than ORB; opposite-sign effects on high-contrast visual encoding (qualitative).",
    "text_access": "abstract_only",
    "study_system": "Mouse, ACA→VISp and ORB→VISp feedback projections; two-photon imaging + chemogenetics",
    "argument_role": "supporting",
    "replication_status": "single-study",
    "claim_source_sentence": "ACA input enhanced visual encoding in VISp neurons and scaled with behavioral arousal, whereas ORB input shaped behavior-related modulation but reduced high-contrast visual encoding.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "We found that ACA axons conveyed stronger visual-stimulus information than ORB axons, though both conveyed non-visual, behavior-related information."
  },
  "section_id": "section_08",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "effect_size": "ACA carries stronger visual-stimulus information than ORB; opposite-sign effects on high-contrast visual encoding (qualitative).",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-8edfacb9362d"
  ],
  "source_span": "ACA input enhanced visual encoding in VISp neurons and scaled with behavioral arousal, whereas ORB input shaped behavior-related modulation but reduced high-contrast visual encoding.",
  "study_system": "Mouse, ACA→VISp and ORB→VISp feedback projections; two-photon imaging + chemogenetics",
  "evidence_refs": [
    {
      "ref": "paper:paper-8edfacb9362d"
    }
  ],
  "section_title": "8. Cross-areal mouse cortico-cortical excitatory connectivity — hierarchical feedforward and feedback as recurrent loops at the network level; Allen Mouse Connectivity Atlas anchored views",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Axonal tracing, two-photon calcium imaging, and chemogenetic manipulations in mice comparing ACA and ORB inputs to VISp.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}