Version history

{
  "scope": "mouse medial prefrontal cortex; in vivo electrophysiology + optogenetics; elevated plus maze",
  "claim_text": "Prefrontal VIP interneuron activity gates hippocampal-prefrontal theta synchrony: optogenetic inhibition of VIP cells decreases open-arm avoidance specifically when hippocampal-prefrontal theta coherence is strong, linking VIP disinhibition to inter-areal theta coordination.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.neuron.2019.04.001",
    "pmid": "31053407",
    "year": "2019",
    "claim": "Prefrontal VIP interneuron activity gates hippocampal-prefrontal theta synchrony: optogenetic inhibition of VIP cells decreases open-arm avoidance specifically when hippocampal-prefrontal theta coherence is strong, linking VIP disinhibition to inter-areal theta coordination.",
    "pmcid": "PMC6800223",
    "title": "VIP Interneurons Contribute to Avoidance Behavior by Regulating Information Flow across Hippocampal-Prefrontal Networks.",
    "authors": "",
    "journal": "",
    "cite_key": "Lee2019",
    "evidence": "Optogenetic inhibition of VIP cells in mPFC during elevated plus-maze with simultaneous mPFC-vHPC LFP recordings.",
    "cluster_id": "cluster_09_oscillations",
    "effect_size": "VIP inhibition decreases open-arm avoidance only at high theta synchrony states",
    "figure_data": [],
    "text_access": "abstract_only",
    "study_system": "mouse medial prefrontal cortex; in vivo electrophysiology + optogenetics; elevated plus maze",
    "cited_by_count": 110,
    "_source_cluster": "cluster_09_oscillations",
    "replication_status": "single-study",
    "_source_cluster_index": 7,
    "claim_source_sentence": "Indeed, inhibiting VIP interneurons disrupts network-level representations of the open arms and decreases open arm avoidance specifically when hippocampal-prefrontal theta synchrony is strong.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "inhibiting VIP interneurons disrupts network-level representations of the open arms and decreases open arm avoidance specifically when hippocampal-prefrontal theta synchrony is strong."
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "effect_size": "VIP inhibition decreases open-arm avoidance only at high theta synchrony states",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-bec295b7a9a9"
  ],
  "source_span": "Indeed, inhibiting VIP interneurons disrupts network-level representations of the open arms and decreases open arm avoidance specifically when hippocampal-prefrontal theta synchrony is strong.",
  "study_system": "mouse medial prefrontal cortex; in vivo electrophysiology + optogenetics; elevated plus maze",
  "evidence_refs": [
    {
      "ref": "paper:paper-bec295b7a9a9"
    }
  ],
  "section_title": "Oscillatory Dynamics and Temporal Coordination",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Optogenetic inhibition of VIP cells in mPFC during elevated plus-maze with simultaneous mPFC-vHPC LFP recordings.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}