Prefrontal VIP interneuron activity gates hippocampal-prefrontal theta synchron…

Prefrontal VIP interneuron activity gates hippocampal-prefrontal theta synchrony: optogenetic inhibition of VIP cells decreases open-arm avoidance specifically when hippocampal-prefrontal theta coherence is strong, linking VIP disinhibition to inter-areal theta coordination.

{
  "n": null,
  "doi": "10.1016/j.neuron.2019.04.001",
  "pmid": "31053407",
  "year": "2019",
  "claim": "Prefrontal VIP interneuron activity gates hippocampal-prefrontal theta synchrony: optogenetic inhibition of VIP cells decreases open-arm avoidance specifically when hippocampal-prefrontal theta coherence is strong, linking VIP disinhibition to inter-areal theta coordination.",
  "pmcid": "PMC6800223",
  "title": "VIP Interneurons Contribute to Avoidance Behavior by Regulating Information Flow across Hippocampal-Prefrontal Networks.",
  "authors": "",
  "journal": "",
  "cite_key": "Lee2019",
  "evidence": "Optogenetic inhibition of VIP cells in mPFC during elevated plus-maze with simultaneous mPFC-vHPC LFP recordings.",
  "cluster_id": "cluster_09_oscillations",
  "effect_size": "VIP inhibition decreases open-arm avoidance only at high theta synchrony states",
  "figure_data": [],
  "text_access": "abstract_only",
  "study_system": "mouse medial prefrontal cortex; in vivo electrophysiology + optogenetics; elevated plus maze",
  "cited_by_count": 110,
  "_source_cluster": "cluster_09_oscillations",
  "replication_status": "single-study",
  "_source_cluster_index": 7,
  "claim_source_sentence": "Indeed, inhibiting VIP interneurons disrupts network-level representations of the open arms and decreases open arm avoidance specifically when hippocampal-prefrontal theta synchrony is strong.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "inhibiting VIP interneurons disrupts network-level representations of the open arms and decreases open arm avoidance specifically when hippocampal-prefrontal theta synchrony is strong."
}

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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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