Analysis of the millimetre-scale MICrONS mouse visual-cortex EM/functional data…

Analysis of the millimetre-scale MICrONS mouse visual-cortex EM/functional dataset shows that excitatory neurons with similar visual response properties are preferentially connected within and across layers and areas, including feedback connections — establishing 'like-to-like' connectivity as a universal rule across the visual hierarchy.

{
  "n": 0,
  "doi": "10.1038/s41586-025-08840-3",
  "claim": "Analysis of the millimetre-scale MICrONS mouse visual-cortex EM/functional dataset shows that excitatory neurons with similar visual response properties are preferentially connected within and across layers and areas, including feedback connections — establishing 'like-to-like' connectivity as a universal rule across the visual hierarchy.",
  "cite_key": "Ding2025",
  "evidence": "Combined EM connectomics and 2P calcium-imaging in MICrONS mouse VISp + HVAs; pairwise and higher-order analyses.",
  "effect_size": "Like-to-like preference across layers and areas; only feature (not spatial) component predicts fine-scale connections beyond axon-dendrite proximity.",
  "text_access": "abstract_only",
  "study_system": "mouse V1 and higher visual areas (VISrl, VISal, VISlm); MICrONS EM + functional 2P",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Here we leverage the millimetre-scale MICrONS dataset to analyse synaptic connectivity and functional properties of neurons across cortical layers and areas. Our results reveal that neurons with similar response properties are preferentially connected within and across layers and areas-including feedback connections-supporting the universality of 'like-to-like' connectivity across the visual hierarchy.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1038/nature09880",
    "10.1038/nature14182",
    "10.1038/nature12015"
  ],
  "effect_size_source_sentence": "We found that only the feature component predicts fine-scale synaptic connections beyond what could be explained by the proximity of axons and dendrites."
}

[
  "paper:paper-7ac22819c082"
]

Here we leverage the millimetre-scale MICrONS dataset to analyse synaptic connectivity and functional properties of neurons across cortical layers and areas. Our results reveal that neurons with similar response properties are preferentially connected within and across layers and areas-including feedback connections-supporting the universality of 'like-to-like' connectivity across the visual hierarchy.

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