Version history

{
  "scope": "Mouse auditory cortex in vivo, fear-conditioning, optogenetics + paired recordings (VIP-Cre)",
  "claim_text": "In auditory cortex, optogenetic activation of VIP interneurons disinhibits pyramidal cells by mainly silencing SST and PV interneurons; reinforcement-related basal forebrain inputs recruit this VIP-mediated disinhibitory motif during behavior.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/nature12676",
    "claim": "In auditory cortex, optogenetic activation of VIP interneurons disinhibits pyramidal cells by mainly silencing SST and PV interneurons; reinforcement-related basal forebrain inputs recruit this VIP-mediated disinhibitory motif during behavior.",
    "title": null,
    "cite_key": "Pi2013",
    "evidence": "VIP-expressing interneurons in auditory cortex are activated by reinforcement signals and mediate disinhibition of pyramidal cells by inhibiting other interneurons.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "Mouse auditory cortex in vivo, fear-conditioning, optogenetics + paired recordings (VIP-Cre)",
    "_source_cluster": "cluster_05_synaptic_connectivity",
    "replication_status": "independently_replicated",
    "_source_cluster_index": 1,
    "claim_source_sentence": "VIP-expressing interneurons in auditory cortex are activated by reinforcement signals and mediate disinhibition of pyramidal cells by inhibiting other interneurons.",
    "replication_evidence_dois": [
      "10.1038/nn.3446",
      "10.1038/nn.3544",
      "10.1126/science.1254126"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-065a0eae69a5"
  ],
  "source_span": "VIP-expressing interneurons in auditory cortex are activated by reinforcement signals and mediate disinhibition of pyramidal cells by inhibiting other interneurons.",
  "study_system": "Mouse auditory cortex in vivo, fear-conditioning, optogenetics + paired recordings (VIP-Cre)",
  "evidence_refs": [
    {
      "ref": "paper:paper-065a0eae69a5"
    }
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "VIP-expressing interneurons in auditory cortex are activated by reinforcement signals and mediate disinhibition of pyramidal cells by inhibiting other interneurons.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}