Spike-timing-dependent LTD in mouse barrel cortex L2/3 pyramidal neurons uses d…

Spike-timing-dependent LTD in mouse barrel cortex L2/3 pyramidal neurons uses different mechanisms at vertical (L4→L2/3) vs horizontal (L2/3→L2/3) excitatory inputs: vertical t-LTD is presynaptic NMDAR-dependent and presynaptically expressed, whereas horizontal t-LTD is postsynaptic NMDAR-dependent and postsynaptically expressed.

{
  "n": 0,
  "doi": "10.1002/phy2.271",
  "claim": "Spike-timing-dependent LTD in mouse barrel cortex L2/3 pyramidal neurons uses different mechanisms at vertical (L4→L2/3) vs horizontal (L2/3→L2/3) excitatory inputs: vertical t-LTD is presynaptic NMDAR-dependent and presynaptically expressed, whereas horizontal t-LTD is postsynaptic NMDAR-dependent and postsynaptically expressed.",
  "cite_key": "Banerjee2014",
  "evidence": "Paired-recording STDP experiments contrasted L4→L2/3 vs L2/3→L2/3 inputs onto the same L2/3 postsynaptic neuron; both showed t-LTD but with different time windows and opposite locus of induction/expression.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "Mouse barrel cortex L2/3 pyramidal neurons, paired recordings (slice)",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Moreover, whereas t-LTD at vertical inputs requires presynaptic NMDA receptors and is expressed presynaptically, using paired recordings we find that t-LTD at horizontal inputs requires postsynaptic NMDA receptors and is expressed postsynaptically.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
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Moreover, whereas t-LTD at vertical inputs requires presynaptic NMDA receptors and is expressed presynaptically, using paired recordings we find that t-LTD at horizontal inputs requires postsynaptic NMDA receptors and is expressed postsynaptically.

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