Forelimb reaching learning in mice increases surface AMPA receptor levels at sp…

{
  "n": 0,
  "doi": "10.1016/j.neuron.2019.12.005",
  "claim": "Forelimb reaching learning in mice increases surface AMPA receptor levels at spatially clustered dendritic spines in motor cortex, and also in visual cortex when visual input is available during training.",
  "cite_key": "Roth2020",
  "evidence": "In vivo two-photon imaging of surface AMPARs during forelimb reaching showed increased AMPAR levels at clustered spines in motor cortex and (visual-input-dependently) in visual cortex; optogenetic inhibition of visual cortex impaired task performance.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "Mouse motor and visual cortex pyramidal-neuron spines during forelimb reaching learning (in vivo two-photon)",
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  "replication_status": "replication_unknown",
  "claim_source_sentence": "Daily training leads to an increase in AMPAR levels at a subset of spatially clustered dendritic spines in the motor cortex.",
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In vivo two-photon imaging of surface AMPARs during forelimb reaching showed increased AMPAR levels at clustered spines in motor cortex and (visual-input-dependently) in visual cortex; optogenetic inhibition of visual cortex impaired task performance.