Details
- scope
- mouse hippocampal basket cells, P6 to P25
- section_id
- section_05_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json
- effect_size
- 30-60% decrease in AP duration, propagation time, release period, and IPSC decay time constant between P6-P25
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-05
- source_kind
- review_finding
- source_path
- evidence/section_05_evidence_package.json
- source_span
- During maturation, action potential duration, propagation time, duration of the release period, and decay time constant of IPSCs decreases by ~30-60%. Thus, postnatal development converts BCs from slow into fast signaling devices.
- study_system
- mouse hippocampal basket cells, P6 to P25
- section_title
- Intrinsic Electrophysiology: The Fast-Spiking Phenotype and Its Variants
- evidence_summary
- Computational analysis showed BC networks with young properties generate lower gamma coherence; mature properties with increased connectivity enable highly coherent upper gamma activity.
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-05
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (5)
- claim_text
Hippocampal basket cells undergo marked changes between P6 and P25: action potential duration, propagation time, release period duration, and IPSC decay time constant decrease by 30-60%, converting BCs from slow to fast signaling devices necessary for gamma oscillations.
- raw_fields
{ "n": 0, "doi": "10.1523/jneurosci.2890-08.2008", "claim": "Hippocampal basket cells undergo marked changes between P6 and P25: action potential duration, propagation time, release period duration, and IPSC decay time constant decrease by 30-60%, converting BCs from slow to fast signaling devices necessary for gamma oscillations.", "evidence": "Computational analysis showed BC networks with young properties generate lower gamma coherence; mature properties with increased connectivity enable highly coherent upper gamma activity.", "effect_size": "30-60% decrease in AP duration, propagation time, release period, and IPSC decay time constant between P6-P25", "text_access": "abstract_only", "study_system": "mouse hippocampal basket cells, P6 to P25", "replication_status": "independently_replicated", "claim_source_sentence": "During maturation, action potential duration, propagation time, duration of the release period, and decay time constant of IPSCs decreases by ~30-60%. Thus, postnatal development converts BCs from slow into fast signaling devices.", "replication_evidence_dois": [ "10.1523/jneurosci.0105-09.2009" ], "effect_size_source_sentence": "action potential duration, propagation time, duration of the release period, and decay time constant of IPSCs decreases by ~30-60%." }- source_refs
[ "paper:paper-7c89812b5c9d" ]
- evidence_refs
[ { "ref": "paper:paper-7c89812b5c9d" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }