Version history

{
  "scope": "mouse cortex; bulk RNA-seq of FACS-sorted populations",
  "claim_text": "Paul et al. (2017) demonstrated that cardinal GABAergic neuron types in mouse cortex are delineated by a transcriptional architecture encoding their synaptic communication patterns, with VIP class subdivided into interneuron-selective disinhibitory (VIP/CR) and CCK basket subpopulations.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.cell.2017.08.032",
    "claim": "Paul et al. (2017) demonstrated that cardinal GABAergic neuron types in mouse cortex are delineated by a transcriptional architecture encoding their synaptic communication patterns, with VIP class subdivided into interneuron-selective disinhibitory (VIP/CR) and CCK basket subpopulations.",
    "title": null,
    "cite_key": "Paul2017",
    "evidence": "Bulk RNA-seq of FACS-sorted Cre-line populations representing 6 cardinal types (PCPs); VIP/CR ISCs and VIP/CCK CCKCs identified as distinct populations within VIP; transcriptional features encoding synaptic input/output gene families distinguish each type.",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "mouse cortex; bulk RNA-seq of FACS-sorted populations",
    "target_section": "section_11",
    "_source_cluster": "cluster_01_molecular_taxonomy",
    "replication_status": "replicated",
    "_source_cluster_index": 23,
    "claim_source_sentence": "We discovered that cardinal GABAergic neuron types are delineated by a transcriptional architecture that encodes their synaptic communication patterns. The HTR3a group includes the Vassoactive intestinal peptide (VIP) and Reelin populations, and the VIP population comprises interneuron-selective dis-inhibitory cells (ISC), Cholecystokinin (CCK) small basket cells (CCKC) and likely additional..."
  },
  "section_id": "section_02",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_02_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-02-classification",
  "source_kind": "review_finding",
  "source_path": "evidence/section_02_evidence_package.json",
  "source_refs": [
    "paper:paper-35a6c66c3e2e"
  ],
  "source_span": "We discovered that cardinal GABAergic neuron types are delineated by a transcriptional architecture that encodes their synaptic communication patterns. The HTR3a group includes the Vassoactive intestinal peptide (VIP) and Reelin populations, and the VIP population comprises interneuron-selective dis-inhibitory cells (ISC), Cholecystokinin (CCK) small basket cells (CCKC) and likely additional...",
  "study_system": "mouse cortex; bulk RNA-seq of FACS-sorted populations",
  "evidence_refs": [
    {
      "ref": "paper:paper-35a6c66c3e2e"
    }
  ],
  "section_title": "Molecular Identity and Transcriptomic Taxonomy",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Bulk RNA-seq of FACS-sorted Cre-line populations representing 6 cardinal types (PCPs); VIP/CR ISCs and VIP/CCK CCKCs identified as distinct populations within VIP; transcriptional features encoding synaptic input/output gene families distinguish each type.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-02-classification",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_02_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}