- claim_text
Paul et al. (2017) demonstrated that cardinal GABAergic neuron types in mouse cortex are delineated by a transcriptional architecture encoding their synaptic communication patterns, with VIP class subdivided into interneuron-selective disinhibitory (VIP/CR) and CCK basket subpopulations.
- raw_fields
{
"n": null,
"doi": "10.1016/j.cell.2017.08.032",
"claim": "Paul et al. (2017) demonstrated that cardinal GABAergic neuron types in mouse cortex are delineated by a transcriptional architecture encoding their synaptic communication patterns, with VIP class subdivided into interneuron-selective disinhibitory (VIP/CR) and CCK basket subpopulations.",
"title": null,
"cite_key": "Paul2017",
"evidence": "Bulk RNA-seq of FACS-sorted Cre-line populations representing 6 cardinal types (PCPs); VIP/CR ISCs and VIP/CCK CCKCs identified as distinct populations within VIP; transcriptional features encoding synaptic input/output gene families distinguish each type.",
"effect_size": null,
"text_access": "fulltext",
"study_system": "mouse cortex; bulk RNA-seq of FACS-sorted populations",
"target_section": "section_11",
"_source_cluster": "cluster_01_molecular_taxonomy",
"replication_status": "replicated",
"_source_cluster_index": 23,
"claim_source_sentence": "We discovered that cardinal GABAergic neuron types are delineated by a transcriptional architecture that encodes their synaptic communication patterns. The HTR3a group includes the Vassoactive intestinal peptide (VIP) and Reelin populations, and the VIP population comprises interneuron-selective dis-inhibitory cells (ISC), Cholecystokinin (CCK) small basket cells (CCKC) and likely additional..."
}- source_refs
[
"paper:paper-35a6c66c3e2e"
]
- source_span
We discovered that cardinal GABAergic neuron types are delineated by a transcriptional architecture that encodes their synaptic communication patterns. The HTR3a group includes the Vassoactive intestinal peptide (VIP) and Reelin populations, and the VIP population comprises interneuron-selective dis-inhibitory cells (ISC), Cholecystokinin (CCK) small basket cells (CCKC) and likely additional...
- evidence_refs
[
{
"ref": "paper:paper-35a6c66c3e2e"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}- evidence_summary
Bulk RNA-seq of FACS-sorted Cre-line populations representing 6 cardinal types (PCPs); VIP/CR ISCs and VIP/CCK CCKCs identified as distinct populations within VIP; transcriptional features encoding synaptic input/output gene families distinguish each type.