Details
- scope
- Healthy controls (n=70) and psychosis patients (schizophrenia spectrum n=75; psychotic bipolar n=49)
- claim_text
- Reduced PFC-thalamic and elevated somatosensory-thalamic anatomical connectivity is a transdiagnostic feature of psychosis present at the early stage of illness in both schizophrenia and psychotic bipolar disorder.
- section_id
- section_14
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-14
- source_kind
- review_finding
- source_path
- evidence/section_14_evidence_package.json
- source_span
- Conclusions Altered thalamocortical anatomical connectivity, especially reduced PFC-thalamic connectivity, is a transdiagnostic feature of psychosis detectable in the early stage of illness.
- study_system
- Healthy controls (n=70) and psychosis patients (schizophrenia spectrum n=75; psychotic bipolar n=49)
- section_title
- Loop Dysfunction in Neurological and Psychiatric Disease
- evidence_summary
- Diffusion-weighted imaging probabilistic tractography in 70 healthy and 124 patients (75 SZ, 49 psychotic bipolar; 62 early-stage).
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-14
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (4)
- raw_fields
{ "n": 194, "doi": "10.1093/schbul/sbaa022", "claim": "Reduced PFC-thalamic and elevated somatosensory-thalamic anatomical connectivity is a transdiagnostic feature of psychosis present at the early stage of illness in both schizophrenia and psychotic bipolar disorder.", "cite_key": "Sheffield2020", "evidence": "Diffusion-weighted imaging probabilistic tractography in 70 healthy and 124 patients (75 SZ, 49 psychotic bipolar; 62 early-stage).", "effect_size": null, "text_access": "fulltext", "study_system": "Healthy controls (n=70) and psychosis patients (schizophrenia spectrum n=75; psychotic bipolar n=49)", "source_cluster_id": "cluster_13", "replication_status": "independently_replicated", "claim_source_sentence": "Conclusions Altered thalamocortical anatomical connectivity, especially reduced PFC-thalamic connectivity, is a transdiagnostic feature of psychosis detectable in the early stage of illness.", "replication_evidence_dois": [ "10.1093/schbul/sby166", "10.1016/j.bpsc.2019.04.012" ], "effect_size_source_sentence": "Methods Diffusion-weighted imaging data were collected on 70 healthy individuals and 124 people with a psychotic disorder (schizophrenia spectrum = 75; psychotic bipolar disorder = 49), including 62 individuals in the early stage of psychosis." }- source_refs
[ "paper:paper-af50f793ecbc" ]
- evidence_refs
[ { "ref": "paper:paper-af50f793ecbc" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }