Version history

{
  "scope": "Healthy controls (n=70) and psychosis patients (schizophrenia spectrum n=75; psychotic bipolar n=49)",
  "claim_text": "Reduced PFC-thalamic and elevated somatosensory-thalamic anatomical connectivity is a transdiagnostic feature of psychosis present at the early stage of illness in both schizophrenia and psychotic bipolar disorder.",
  "raw_fields": {
    "n": 194,
    "doi": "10.1093/schbul/sbaa022",
    "claim": "Reduced PFC-thalamic and elevated somatosensory-thalamic anatomical connectivity is a transdiagnostic feature of psychosis present at the early stage of illness in both schizophrenia and psychotic bipolar disorder.",
    "cite_key": "Sheffield2020",
    "evidence": "Diffusion-weighted imaging probabilistic tractography in 70 healthy and 124 patients (75 SZ, 49 psychotic bipolar; 62 early-stage).",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "Healthy controls (n=70) and psychosis patients (schizophrenia spectrum n=75; psychotic bipolar n=49)",
    "source_cluster_id": "cluster_13",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Conclusions Altered thalamocortical anatomical connectivity, especially reduced PFC-thalamic connectivity, is a transdiagnostic feature of psychosis detectable in the early stage of illness.",
    "replication_evidence_dois": [
      "10.1093/schbul/sby166",
      "10.1016/j.bpsc.2019.04.012"
    ],
    "effect_size_source_sentence": "Methods Diffusion-weighted imaging data were collected on 70 healthy individuals and 124 people with a psychotic disorder (schizophrenia spectrum = 75; psychotic bipolar disorder = 49), including 62 individuals in the early stage of psychosis."
  },
  "section_id": "section_14",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-14",
  "source_kind": "review_finding",
  "source_path": "evidence/section_14_evidence_package.json",
  "source_refs": [
    "paper:paper-af50f793ecbc"
  ],
  "source_span": "Conclusions Altered thalamocortical anatomical connectivity, especially reduced PFC-thalamic connectivity, is a transdiagnostic feature of psychosis detectable in the early stage of illness.",
  "study_system": "Healthy controls (n=70) and psychosis patients (schizophrenia spectrum n=75; psychotic bipolar n=49)",
  "evidence_refs": [
    {
      "ref": "paper:paper-af50f793ecbc"
    }
  ],
  "section_title": "Loop Dysfunction in Neurological and Psychiatric Disease",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Diffusion-weighted imaging probabilistic tractography in 70 healthy and 124 patients (75 SZ, 49 psychotic bipolar; 62 early-stage).",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-14",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}