In awake behaving mouse V1, locomotion increases activity of VIP, SST and PV in…

In awake behaving mouse V1, locomotion increases activity of VIP, SST and PV interneurons during visual stimulation, contradicting the simple disinhibition (VIP→SST→Pyr) model; in darkness most VIP and PV neurons remain locomotion-responsive while SST and excitatory neurons are largely non-responsive — context-dependent disinhibition.

{
  "n": null,
  "doi": "10.7554/elife.14985",
  "claim": "In awake behaving mouse V1, locomotion increases activity of VIP, SST and PV interneurons during visual stimulation, contradicting the simple disinhibition (VIP→SST→Pyr) model; in darkness most VIP and PV neurons remain locomotion-responsive while SST and excitatory neurons are largely non-responsive — context-dependent disinhibition.",
  "title": null,
  "cite_key": "Pakan2016",
  "evidence": "In vivo 2P GCaMP6f imaging in L2/3 and L4 of V1 in head-fixed running mice; visual stimuli vs darkness conditions.",
  "effect_size": "Context dependence: SST suppression by VIP only manifest in darkness, not during visual stimulation.",
  "text_access": "fulltext",
  "study_system": "mouse V1 L2/3 and L4; awake in vivo 2P",
  "_source_cluster": "cluster_05_synaptic_connectivity",
  "replication_status": "replicates",
  "_source_cluster_index": 36,
  "claim_source_sentence": "Using in vivo two-photon calcium imaging in layers 2/3 and 4 in mouse V1, we reveal that locomotion increases the activity of vasoactive intestinal peptide (VIP), somatostatin (SST) and parvalbumin (PV)-positive interneurons during visual stimulation, challenging the disinhibition model. In darkness, while most VIP and PV neurons remained locomotion responsive, SST and excitatory neurons were largely non-responsive.",
  "replication_evidence_dois": [
    "10.1016/j.neuron.2018.03.037",
    "10.1016/j.cell.2014.01.050"
  ],
  "effect_size_source_sentence": null
}

[
  "paper:paper-acf576c0a2ed"
]

Using in vivo two-photon calcium imaging in layers 2/3 and 4 in mouse V1, we reveal that locomotion increases the activity of vasoactive intestinal peptide (VIP), somatostatin (SST) and parvalbumin (PV)-positive interneurons during visual stimulation, challenging the disinhibition model. In darkness, while most VIP and PV neurons remained locomotion responsive, SST and excitatory neurons were largely non-responsive.

[
  {
    "ref": "paper:paper-acf576c0a2ed"
  }
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}