Version history

{
  "scope": "mouse V1 L2/3 and L4; awake in vivo 2P",
  "claim_text": "In awake behaving mouse V1, locomotion increases activity of VIP, SST and PV interneurons during visual stimulation, contradicting the simple disinhibition (VIP→SST→Pyr) model; in darkness most VIP and PV neurons remain locomotion-responsive while SST and excitatory neurons are largely non-responsive — context-dependent disinhibition.",
  "raw_fields": {
    "n": null,
    "doi": "10.7554/elife.14985",
    "claim": "In awake behaving mouse V1, locomotion increases activity of VIP, SST and PV interneurons during visual stimulation, contradicting the simple disinhibition (VIP→SST→Pyr) model; in darkness most VIP and PV neurons remain locomotion-responsive while SST and excitatory neurons are largely non-responsive — context-dependent disinhibition.",
    "title": null,
    "cite_key": "Pakan2016",
    "evidence": "In vivo 2P GCaMP6f imaging in L2/3 and L4 of V1 in head-fixed running mice; visual stimuli vs darkness conditions.",
    "effect_size": "Context dependence: SST suppression by VIP only manifest in darkness, not during visual stimulation.",
    "text_access": "fulltext",
    "study_system": "mouse V1 L2/3 and L4; awake in vivo 2P",
    "_source_cluster": "cluster_05_synaptic_connectivity",
    "replication_status": "replicates",
    "_source_cluster_index": 36,
    "claim_source_sentence": "Using in vivo two-photon calcium imaging in layers 2/3 and 4 in mouse V1, we reveal that locomotion increases the activity of vasoactive intestinal peptide (VIP), somatostatin (SST) and parvalbumin (PV)-positive interneurons during visual stimulation, challenging the disinhibition model. In darkness, while most VIP and PV neurons remained locomotion responsive, SST and excitatory neurons were largely non-responsive.",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2018.03.037",
      "10.1016/j.cell.2014.01.050"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "effect_size": "Context dependence: SST suppression by VIP only manifest in darkness, not during visual stimulation.",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-acf576c0a2ed"
  ],
  "source_span": "Using in vivo two-photon calcium imaging in layers 2/3 and 4 in mouse V1, we reveal that locomotion increases the activity of vasoactive intestinal peptide (VIP), somatostatin (SST) and parvalbumin (PV)-positive interneurons during visual stimulation, challenging the disinhibition model. In darkness, while most VIP and PV neurons remained locomotion responsive, SST and excitatory neurons were largely non-responsive.",
  "study_system": "mouse V1 L2/3 and L4; awake in vivo 2P",
  "evidence_refs": [
    {
      "ref": "paper:paper-acf576c0a2ed"
    }
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "In vivo 2P GCaMP6f imaging in L2/3 and L4 of V1 in head-fixed running mice; visual stimuli vs darkness conditions.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicates",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}